iGMDRD794

Canonical SMILES: CC1CN(CC2=C1N(N=C2C(=O)NC3=CC=CC(=C3)C(C)O)CC4=CC=C(C=C4)F)C(=O)C5=CC=CN5

InChI: InChI=1S/C28H28FN5O3/c1-17-14-33(28(37)24-7-4-12-30-24)16-23-25(27(36)31-22-6-3-5-20(13-22)18(2)35)32-34(26(17)23)15-19-8-10-21(29)11-9-19/h3-13,17-18,30,35H,14-16H2,1-2H3,(H,31,36)/t17-,18+/m1/s1

InChI Key: IVFDDVKCCBDPQZ-MSOLQXFVSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameGSK321
Pubchem CID91864700
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: Acute Myeloid Leukemia (AML) model num: 1

Drug-gene pathway enrichments

2reactome: Metabolism of proteins2reactome: Peroxisomal protein import1reactome: Innate Immune System1reactome: Immune System1reactome: Metabolism1kegg: Central carbon metabolism in cancer - Homo sapiens (human)1reactome: Metabolism of vitamins and cofactors1reactome: Disease1reactome: NADPH regeneration1reactome: Metabolism of cofactors

Drug-gene GO enrichments

2BP: 2-oxoglutarate metabolic process2CC: cytosol2MF: isocitrate dehydrogenase (NADP+) activity1BP: protein targeting to peroxisome1BP: isocitrate metabolic process1BP: tricarboxylic acid cycle1BP: glyoxylate cycle1BP: NADPH regeneration1CC: ficolin-1-rich granule lumen1BP: glutathione metabolic process

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3417 IDH1 1
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Gene in drug-gene network: Network Plot

Models in GSK321

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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