Summary: This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].


GO terms in MSLN

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
BPNASGO:0007155cell adhesion
BPIBAGO:0007160cell-matrix adhesion
BPIEAGO:0031016pancreas development
BPTASGO:0043687post-translational protein modification
BPTASGO:0044267cellular protein metabolic process
CCTASGO:0005576extracellular region
CCIEAGO:0005615extracellular space
CCTASGO:0005788endoplasmic reticulum lumen
CCIEAGO:0005794Golgi apparatus
CCTASGO:0005886plasma membrane
CCIBAGO:0009986cell surface
CCIEAGO:0031225anchored component of membrane

Gene expression in normal tissue: MSLN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MSLN

DatabasePathway IDPathway Des.
reactomeR-HSA-163125Post-translational modification: synthesis of GPI-anchored proteins
reactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8957275Post-translational protein phosphorylation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MSLN