RGS14
Summary: This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602513 Ensembl IDEnsembl:ENSG00000169220 HGNC IDHGNC:HGNC:9996 PHARMGKB IDPA34366 Map Location5q35.3 | |||||
GO terms in RGS14
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000278 | mitotic cell cycle |
| BP | ISS | GO:0006913 | nucleocytoplasmic transport |
| BP | ISS | GO:0006979 | response to oxidative stress |
| BP | IMP | GO:0007051 | spindle organization |
| BP | ISS | GO:0007059 | chromosome segregation |
| BP | ISS | GO:0007612 | learning |
Gene expression in normal tissue: RGS14
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RGS14
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD536 | PLX-4720 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RGS14
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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