RGS14
Summary: This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| regulator of G protein signaling 14 | MIM:602513 | Ensembl:ENSG00000169220 | HGNC:HGNC:9996 | PA34366 | 5q35.3 |
GO terms in RGS14
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000278 | mitotic cell cycle |
| BP | ISS | GO:0006913 | nucleocytoplasmic transport |
| BP | ISS | GO:0006979 | response to oxidative stress |
| BP | IMP | GO:0007051 | spindle organization |
| BP | ISS | GO:0007059 | chromosome segregation |
| BP | ISS | GO:0007612 | learning |
| BP | ISS | GO:0007616 | long-term memory |
| BP | TAS | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway |
| BP | ISS | GO:0008542 | visual learning |
| BP | ISS | GO:0010070 | zygote asymmetric cell division |
| BP | ISS | GO:0031914 | negative regulation of synaptic plasticity |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0043407 | negative regulation of MAP kinase activity |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | ISS | GO:0043620 | regulation of DNA-templated transcription in response to stress |
| BP | ISS | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway |
| BP | ISS | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| BP | ISS | GO:0050769 | positive regulation of neurogenesis |
| BP | IMP | GO:0051301 | cell division |
| BP | ISS | GO:0060291 | long-term synaptic potentiation |
| BP | ISS | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| CC | ISS | GO:0000922 | spindle pole |
| CC | ISS | GO:0005634 | nucleus |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005813 | centrosome |
| CC | IDA | GO:0005819 | spindle |
| CC | IEA | GO:0005874 | microtubule |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0014069 | postsynaptic density |
| CC | ISS | GO:0016604 | nuclear body |
| CC | IEA | GO:0016605 | PML body |
| CC | IEA | GO:0030054 | cell junction |
| CC | ISS | GO:0030425 | dendrite |
| CC | ISS | GO:0043197 | dendritic spine |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| MF | IEA | GO:0001965 | G-protein alpha-subunit binding |
| MF | IDA | GO:0005092 | GDP-dissociation inhibitor activity |
| MF | IDA | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008017 | microtubule binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | ISS | GO:0030159 | receptor signaling complex scaffold activity |
| MF | IEA | GO:0032794 | GTPase activating protein binding |
Gene expression in normal tissue: RGS14
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RGS14
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RGS14
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