DLL3
Summary: This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602768 Ensembl IDEnsembl:ENSG00000090932 HGNC IDHGNC:HGNC:2909 PHARMGKB IDPA27365 Map Location19q13.2 | |||||
GO terms in DLL3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0005112 | Notch binding |
| MF | IEA | GO:0005509 | calcium ion binding |
| BP | IMP | GO:0001501 | skeletal system development |
| BP | IEA | GO:0001756 | somitogenesis |
| BP | IEA | GO:0007219 | Notch signaling pathway |
| BP | IEA | GO:0007386 | compartment pattern specification |
Gene expression in normal tissue: DLL3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DLL3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP3413 | NOTCH1 regulation of human endothelial cell calcification |
| wikipathways | WP3845 | Canonical and Non-canonical Notch signaling |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP4242 | Notch Signaling Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DLL3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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