DLL3


Summary: This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
delta like canonical Notch ligand 3MIM:602768Ensembl:ENSG00000090932HGNC:HGNC:2909PA2736519q13.2

GO terms in DLL3


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0005112Notch binding
MFIEAGO:0005509calcium ion binding
BPIMPGO:0001501skeletal system development
BPIEAGO:0001756somitogenesis
BPIEAGO:0007219Notch signaling pathway
BPIEAGO:0007386compartment pattern specification
BPIEAGO:0048339paraxial mesoderm development
BPIEAGO:0050768negative regulation of neurogenesis
CCNASGO:0016021integral component of membrane

Gene expression in normal tissue: DLL3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DLL3


DatabasePathway IDPathway Des.
wikipathwaysWP2064Neural Crest Differentiation
wikipathwaysWP268Notch Signaling Pathway
wikipathwaysWP3413NOTCH1 regulation of human endothelial cell calcification
wikipathwaysWP3845Canonical and Non-canonical Notch signaling
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP4242Notch Signaling Pathway
wikipathwaysWP61Notch Signaling Pathway
kegghsa04330Notch signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
pidnotch_pathwayNotch signaling pathway
netpathPathway_NotchNotch

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1
iGMDRD491TAE-6841

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DLL3

​​​​