UGT2B11
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| UDP glucuronosyltransferase family 2 member B11 | MIM:603064 | Ensembl:ENSG00000213759 | HGNC:HGNC:12545 | PA37187 | 4q13.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in UGT2B11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006805 | xenobiotic metabolic process |
| BP | IDA | GO:0008210 | estrogen metabolic process |
| BP | IDA | GO:0052697 | xenobiotic glucuronidation |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0031090 | organelle membrane |
| CC | IBA | GO:0043231 | intracellular membrane-bounded organelle |
| MF | IBA | GO:0008194 | UDP-glycosyltransferase activity |
| MF | IDA | GO:0015020 | glucuronosyltransferase activity |
Gene expression in normal tissue: UGT2B11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UGT2B11
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156580 | Phase II - Conjugation of compounds |
| reactome | R-HSA-156588 | Glucuronidation |
| reactome | R-HSA-211859 | Biological oxidations |
| humancyc | PWY-6261 | thyroid hormone metabolism II (via conjugation and/or degradation) |
| humancyc | PWY-6313 | serotonin degradation |
| humancyc | PWY-6398 | melatonin degradation I |
| humancyc | PWY-6402 | superpathway of melatonin degradation |
| humancyc | PWY66-201 | nicotine degradation IV |
| humancyc | PWY66-221 | nicotine degradation III |
| humancyc | PWY66-401 | superpathway of tryptophan utilization |
| kegg | hsa00040 | Pentose and glucuronate interconversions - Homo sapiens (human) |
| kegg | hsa00053 | Ascorbate and aldarate metabolism - Homo sapiens (human) |
| kegg | hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| kegg | hsa00830 | Retinol metabolism - Homo sapiens (human) |
| kegg | hsa00860 | Porphyrin and chlorophyll metabolism - Homo sapiens (human) |
| kegg | hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00982 | Drug metabolism - cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| kegg | hsa05204 | Chemical carcinogenesis - Homo sapiens (human) |
| smpdb | SMP00024 | Porphyrin Metabolism |
| smpdb | SMP00058 | Starch and Sucrose Metabolism |
| smpdb | SMP00068 | Androgen and Estrogen Metabolism |
| smpdb | SMP00342 | Hereditary Coproporphyria (HCP) |
| smpdb | SMP00344 | Acute Intermittent Porphyria |
| smpdb | SMP00345 | Congenital Erythropoietic Porphyria (CEP) or Gunther Disease |
| smpdb | SMP00346 | Porphyria Variegata (PV) |
| smpdb | SMP00356 | 17-Beta Hydroxysteroid Dehydrogenase III Deficiency |
| smpdb | SMP00552 | Glycogen synthetase deficiency |
| smpdb | SMP00553 | Glycogenosis, Type III. Cori disease, Debrancher glycogenosis |
| smpdb | SMP00554 | Glycogenosis, Type IV. Amylopectinosis, Anderson disease |
| smpdb | SMP00555 | Glycogenosis, Type VI. Hers disease |
| smpdb | SMP00556 | Mucopolysaccharidosis VI. Sly syndrome |
| smpdb | SMP00557 | Sucrase-isomaltase deficiency |
| smpdb | SMP00565 | Aromatase deficiency |
| wikipathways | WP698 | Glucuronidation |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UGT2B11
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.