IQGAP2
Summary: This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| IQ motif containing GTPase activating protein 2 | MIM:605401 | Ensembl:ENSG00000145703 | HGNC:HGNC:6111 | PA29911 | 5q13.3 |
Gene Categories:
CELL SURFACEGO terms in IQGAP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003779 | actin binding |
| MF | TAS | GO:0005095 | GTPase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0005516 | calmodulin binding |
| MF | IDA | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding |
| MF | IDA | GO:0017048 | Rho GTPase binding |
| MF | IDA | GO:0048365 | Rac GTPase binding |
| MF | IDA | GO:0051015 | actin filament binding |
| MF | IDA | GO:0071933 | Arp2/3 complex binding |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005902 | microvillus |
| CC | IDA | GO:0009986 | cell surface |
| CC | TAS | GO:0015629 | actin cytoskeleton |
| CC | IDA | GO:0030027 | lamellipodium |
| CC | IDA | GO:0030175 | filopodium |
| CC | TAS | GO:0030667 | secretory granule membrane |
| CC | IDA | GO:0031941 | filamentous actin |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0034260 | negative regulation of GTPase activity |
| BP | IDA | GO:0034314 | Arp2/3 complex-mediated actin nucleation |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IDA | GO:0070493 | thrombin-activated receptor signaling pathway |
Gene expression in normal tissue: IQGAP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IQGAP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-5626467 | RHO GTPases activate IQGAPs |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| wikipathways | WP524 | G13 Signaling Pathway |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IQGAP2
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