PACSIN2
Summary: This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase C and casein kinase substrate in neurons 2 | MIM:604960 | Ensembl:ENSG00000100266 | HGNC:HGNC:8571 | PA32897 | 22q13.2 |
Gene Categories:
TRANSPORTERGO terms in PACSIN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005215 | transporter activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005543 | phospholipid binding |
| MF | IBA | GO:0008092 | cytoskeletal protein binding |
| MF | IEA | GO:0008092 | cytoskeletal protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IDA | GO:0070300 | phosphatidic acid binding |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005768 | endosome |
| CC | IEA | GO:0005769 | early endosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005856 | cytoskeleton |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005901 | caveola |
| CC | IEA | GO:0005911 | cell-cell junction |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | ISS | GO:0019898 | extrinsic component of membrane |
| CC | IEA | GO:0030659 | cytoplasmic vesicle membrane |
| CC | IEA | GO:0032587 | ruffle membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IDA | GO:0055038 | recycling endosome membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IBA | GO:0007010 | cytoskeleton organization |
| BP | IEA | GO:0030036 | actin cytoskeleton organization |
| BP | IBA | GO:0030100 | regulation of endocytosis |
| BP | IMP | GO:0036010 | protein localization to endosome |
| BP | IEA | GO:0045806 | negative regulation of endocytosis |
| BP | ISS | GO:0048858 | cell projection morphogenesis |
| BP | TAS | GO:0061024 | membrane organization |
| BP | IMP | GO:0070836 | caveola assembly |
| BP | IMP | GO:0072584 | caveolin-mediated endocytosis |
| BP | IBA | GO:0097320 | plasma membrane tubulation |
| BP | IDA | GO:0097320 | plasma membrane tubulation |
| BP | ISS | GO:0097320 | plasma membrane tubulation |
Gene expression in normal tissue: PACSIN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PACSIN2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PACSIN2
CLASSFICATION
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