SORCS1


Summary: This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
sortilin related VPS10 domain containing receptor 1MIM:606283Ensembl:ENSG00000108018HGNC:HGNC:16697PA13486128410q25.1

GO terms in SORCS1


Term TypeEvidence TypeGO Term IDGO Des.
BPNASGO:0007218neuropeptide signaling pathway
CCIDAGO:0016020membrane
CCIEAGO:0016021integral component of membrane
MFIPIGO:0005515protein binding
MFNASGO:0008188neuropeptide receptor activity

Gene expression in normal tissue: SORCS1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SORCS1


DatabasePathway IDPathway Des.
wikipathwaysWP2858Ectoderm Differentiation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD491TAE-6841

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SORCS1

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