CPOX
Summary: The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).[provided by RefSeq, Oct 2009].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:612732 Ensembl IDEnsembl:ENSG00000080819 HGNC IDHGNC:HGNC:2321 PHARMGKB IDPA134979958 Map Location3q11.2 | |||||
GO terms in CPOX
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004109 | coproporphyrinogen oxidase activity |
| MF | TAS | GO:0004109 | coproporphyrinogen oxidase activity |
| MF | IEA | GO:0005212 | structural constituent of eye lens |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| BP | IEA | GO:0006782 | protoporphyrinogen IX biosynthetic process |
| BP | TAS | GO:0006783 | heme biosynthetic process |
Gene expression in normal tissue: CPOX
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CPOX
Loading, please wait...
Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00024 | Porphyrin Metabolism |
| smpdb | SMP00342 | Hereditary Coproporphyria (HCP) |
| smpdb | SMP00344 | Acute Intermittent Porphyria |
| smpdb | SMP00345 | Congenital Erythropoietic Porphyria (CEP) or Gunther Disease |
| smpdb | SMP00346 | Porphyria Variegata (PV) |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
Gene-Drug: Aster Plot
Loading, please wait...
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD491 | TAE-684 | 1 |
Showing 1 to 1 of 1 rows
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CPOX
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.