CTSH
Summary: The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namecathepsin H OMIM IDMIM:116820 Ensembl IDEnsembl:ENSG00000103811 HGNC IDHGNC:HGNC:2535 PHARMGKB IDPA27033 Map Location15q25.1 | |||||
GO terms in CTSH
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0001656 | metanephros development |
| BP | ISS | GO:0001913 | T cell mediated cytotoxicity |
| BP | IEP | GO:0002250 | adaptive immune response |
| BP | IDA | GO:0002764 | immune response-regulating signaling pathway |
| BP | IDA | GO:0006508 | proteolysis |
| BP | TAS | GO:0006508 | proteolysis |
Gene expression in normal tissue: CTSH
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CTSH
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04142 | Lysosome - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2132295 | MHC class II antigen presentation |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD409 | Saracatinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CTSH
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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