PPM1L
Summary: The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein phosphatase, Mg2+/Mn2+ dependent 1L | MIM:611931 | Ensembl:ENSG00000163590 | HGNC:HGNC:16381 | PA134871016 | 3q25.33-q26.1 |
Gene Categories:
PROTEIN PHOSPHATASEGO terms in PPM1L
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004722 | protein serine/threonine phosphatase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0006470 | protein dephosphorylation |
| BP | IEA | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway |
| BP | TAS | GO:0030148 | sphingolipid biosynthetic process |
Gene expression in normal tissue: PPM1L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPM1L
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3925 | Amino Acid metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1660661 | Sphingolipid de novo biosynthesis |
| reactome | R-HSA-428157 | Sphingolipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPM1L
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