DHX9

Summary: This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameDExH-box helicase 9
OMIM IDMIM:603115
Ensembl IDEnsembl:ENSG00000135829
HGNC IDHGNC:HGNC:2750
PHARMGKB IDPA27232
Map Location1q25.3

GO terms in DHX9


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF IDA GO:0000993 RNA polymerase II core binding
MF IDA GO:0001069 regulatory region RNA binding
MF IPI GO:0001085 RNA polymerase II transcription factor binding
MF ISS GO:0003677 DNA binding
MF IDA GO:0003688 DNA replication origin binding
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Gene expression in normal tissue: DHX9

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

Other, kinases1Biosynthesis of alkaloids derived from shikimate pathway1

Pathways in DHX9


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
reactome R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
reactome R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD63 Camptothecin 1
iGMDRD371 THR1 Inhibitor 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DHX9

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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