DNASE1L3
Summary: This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| deoxyribonuclease 1 like 3 | MIM:602244 | Ensembl:ENSG00000163687 | HGNC:HGNC:2959 | PA27430 | 3p14.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in DNASE1L3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005576 | extracellular region |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| BP | IBA | GO:0000737 | DNA catabolic process, endonucleolytic |
| BP | ISS | GO:0002283 | neutrophil activation involved in immune response |
| BP | ISS | GO:0002673 | regulation of acute inflammatory response |
| BP | TAS | GO:0006259 | DNA metabolic process |
| BP | IBA | GO:0006308 | DNA catabolic process |
| BP | IBA | GO:0006309 | apoptotic DNA fragmentation |
| BP | IDA | GO:0006309 | apoptotic DNA fragmentation |
| BP | IBA | GO:0010623 | programmed cell death involved in cell development |
| BP | IEA | GO:0010623 | programmed cell death involved in cell development |
| BP | ISS | GO:0070948 | regulation of neutrophil mediated cytotoxicity |
| MF | IBA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0004520 | endodeoxyribonuclease activity |
| MF | IBA | GO:0004530 | deoxyribonuclease I activity |
| MF | IBA | GO:0004536 | deoxyribonuclease activity |
| MF | TAS | GO:0004536 | deoxyribonuclease activity |
| MF | TAS | GO:0005509 | calcium ion binding |
Gene expression in normal tissue: DNASE1L3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DNASE1L3
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DNASE1L3
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.