CELSR3
Summary: This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cadherin EGF LAG seven-pass G-type receptor 3 | MIM:604264 | Ensembl:ENSG00000008300 | HGNC:HGNC:3230 | PA26395 | 3p21.31 |
GO terms in CELSR3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004930 | G-protein coupled receptor activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IEA | GO:0001764 | neuron migration |
| BP | IEA | GO:0001932 | regulation of protein phosphorylation |
| BP | IEA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | IEA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0007413 | axonal fasciculation |
| BP | IEA | GO:0032880 | regulation of protein localization |
| BP | IEA | GO:0036514 | dopaminergic neuron axon guidance |
| BP | IEA | GO:0036515 | serotonergic neuron axon guidance |
| BP | NAS | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
| BP | IEA | GO:0060271 | cilium assembly |
| BP | IEA | GO:1904938 | planar cell polarity pathway involved in axon guidance |
Gene expression in normal tissue: CELSR3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CELSR3
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