APLF
Summary: C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| aprataxin and PNKP like factor | MIM:611035 | Ensembl:ENSG00000169621 | HGNC:HGNC:28724 | PA164715842 | 2p13.3 |
Gene Categories:
DNA REPAIRGO terms in APLF
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000166 | nucleotide binding |
| MF | IBA | GO:0003906 | DNA-(apurinic or apyrimidinic site) endonuclease activity |
| MF | IDA | GO:0003906 | DNA-(apurinic or apyrimidinic site) endonuclease activity |
| MF | IDA | GO:0004520 | endodeoxyribonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008408 | 3'-5' exonuclease activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0140078 | class I DNA-(apurinic or apyrimidinic site) endonuclease activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005829 | cytosol |
| CC | IBA | GO:0035861 | site of double-strand break |
| CC | IDA | GO:0035861 | site of double-strand break |
| BP | IMP | GO:0000012 | single strand break repair |
| BP | IBA | GO:0006302 | double-strand break repair |
| BP | IMP | GO:0006302 | double-strand break repair |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0045191 | regulation of isotype switching |
| BP | IGI | GO:0051106 | positive regulation of DNA ligation |
| BP | IEA | GO:0090305 | nucleic acid phosphodiester bond hydrolysis |
Gene expression in normal tissue: APLF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in APLF
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | dnapk_pathway | DNA-PK pathway in nonhomologous end joining |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in APLF
CLASSFICATION
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