ALDH9A1

Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namealdehyde dehydrogenase 9 family member A1
OMIM IDMIM:602733
Ensembl IDEnsembl:ENSG00000143149
HGNC IDHGNC:HGNC:412
PHARMGKB IDPA24706
Map Location1q24.1

Gene Categories:

DRUGGABLE GENOME

GO terms in ALDH9A1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0006081 cellular aldehyde metabolic process
BP IDA GO:0042136 neurotransmitter biosynthetic process
BP TAS GO:0042445 hormone metabolic process
BP IEA GO:0045329 carnitine biosynthetic process
BP TAS GO:0045329 carnitine biosynthetic process
BP IDA GO:0055114 oxidation-reduction process
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Gene expression in normal tissue: ALDH9A1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

RTK signaling1

Pathways in ALDH9A1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-70895 Branched-chain amino acid catabolism
reactome R-HSA-71262 Carnitine synthesis
reactome R-HSA-71291 Metabolism of amino acids and derivatives
kegg hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human)
kegg hsa00053 Ascorbate and aldarate metabolism - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD409 Saracatinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ALDH9A1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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