FGA


Summary: This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:134820
PHARMGKB IDPA429
Map Location4q31.3

GO terms in FGA


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0005102 signaling receptor binding
MF IDA GO:0005198 structural molecule activity
MF IMP GO:0005198 structural molecule activity
MF IPI GO:0005515 protein binding
MF IEA GO:0046872 metal ion binding
MF IDA GO:0050839 cell adhesion molecule binding
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Gene expression in normal tissue: FGA

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Pathways in FGA


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Database
Pathway ID
Pathway Des.
pid integrin1_pathway Beta1 integrin cell surface interactions
pid integrin2_pathway Beta2 integrin cell surface interactions
pid integrin3_pathway Beta3 integrin cell surface interactions
pid upa_upar_pathway Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
pharmgkb PA154444041 Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
kegg hsa04610 Complement and coagulation cascades - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD491 TAE-684 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FGA

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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