FGA
Summary: This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| fibrinogen alpha chain | MIM:134820 | Ensembl:ENSG00000171560 | HGNC:HGNC:3661 | PA429 | 4q31.3 |
GO terms in FGA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0005102 | signaling receptor binding |
| MF | IDA | GO:0005198 | structural molecule activity |
| MF | IMP | GO:0005198 | structural molecule activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:0050839 | cell adhesion molecule binding |
| BP | TAS | GO:0002224 | toll-like receptor signaling pathway |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | IDA | GO:0007160 | cell-matrix adhesion |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | IDA | GO:0031639 | plasminogen activation |
| BP | IDA | GO:0034116 | positive regulation of heterotypic cell-cell adhesion |
| BP | IDA | GO:0034622 | cellular protein-containing complex assembly |
| BP | IDA | GO:0042730 | fibrinolysis |
| BP | IDA | GO:0043152 | induction of bacterial agglutination |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IDA | GO:0045907 | positive regulation of vasoconstriction |
| BP | IDA | GO:0045921 | positive regulation of exocytosis |
| BP | IDA | GO:0050714 | positive regulation of protein secretion |
| BP | IDA | GO:0051258 | protein polymerization |
| BP | IDA | GO:0051592 | response to calcium ion |
| BP | IMP | GO:0065003 | protein-containing complex assembly |
| BP | IDA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | HMP | GO:0070527 | platelet aggregation |
| BP | IDA | GO:0070527 | platelet aggregation |
| BP | IMP | GO:0072377 | blood coagulation, common pathway |
| BP | IDA | GO:0072378 | blood coagulation, fibrin clot formation |
| BP | IDA | GO:0090277 | positive regulation of peptide hormone secretion |
| BP | NAS | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| BP | IDA | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IDA | GO:2000352 | negative regulation of endothelial cell apoptotic process |
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005577 | fibrinogen complex |
| CC | IDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005938 | cell cortex |
| CC | IDA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0031091 | platelet alpha granule |
| CC | TAS | GO:0031093 | platelet alpha granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | HDA | GO:0072562 | blood microparticle |
| CC | HDA | GO:1903561 | extracellular vesicle |
Gene expression in normal tissue: FGA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FGA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | integrin1_pathway | Beta1 integrin cell surface interactions |
| pid | integrin2_pathway | Beta2 integrin cell surface interactions |
| pid | integrin3_pathway | Beta3 integrin cell surface interactions |
| pid | upa_upar_pathway | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| pharmgkb | PA154444041 | Platelet Aggregation Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa04610 | Complement and coagulation cascades - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| smpdb | SMP00268 | Warfarin Action Pathway |
| smpdb | SMP00269 | Acenocoumarol Action Pathway |
| smpdb | SMP00270 | Dicumarol Action Pathway |
| smpdb | SMP00271 | Phenprocoumon Action Pathway |
| smpdb | SMP00272 | Enoxaparin Action Pathway |
| smpdb | SMP00273 | Fondaparinux Action Pathway |
| smpdb | SMP00274 | Heparin Action Pathway |
| smpdb | SMP00275 | Ardeparin Action Pathway |
| smpdb | SMP00276 | Argatroban Action Pathway |
| smpdb | SMP00277 | Bivalirudin Action Pathway |
| smpdb | SMP00278 | Lepirudin Action Pathway |
| smpdb | SMP00279 | Ximelagatran Action Pathway |
| smpdb | SMP00280 | Alteplase Action Pathway |
| smpdb | SMP00281 | Anistreplase Action Pathway |
| smpdb | SMP00282 | Streptokinase Action Pathway |
| smpdb | SMP00283 | Tenecteplase Action Pathway |
| smpdb | SMP00284 | Urokinase Action Pathway |
| smpdb | SMP00285 | Reteplase Action Pathway |
| smpdb | SMP00286 | Aminocaproic Acid Action Pathway |
| smpdb | SMP00287 | Tranexamic Acid Action Pathway |
| smpdb | SMP00288 | Aprotinin Action Pathway |
| smpdb | SMP00586 | Coagulation |
| smpdb | SMP00655 | Phenindione Action Pathway |
| smpdb | SMP00656 | Dicoumarol Action Pathway |
| wikipathways | WP272 | Blood Clotting Cascade |
| wikipathways | WP2806 | Human Complement System |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3897 | Dengue-2 Interactions with Blood Clotting Cascade |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-140875 | Common Pathway of Fibrin Clot Formation |
| reactome | R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-354192 | Integrin alphaIIb beta3 signaling |
| reactome | R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins |
| reactome | R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5674135 | MAP2K and MAPK activation |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-5686938 | Regulation of TLR by endogenous ligand |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants |
| reactome | R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants |
| reactome | R-HSA-6802949 | Signaling by RAS mutants |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-76009 | Platelet Aggregation (Plug Formation) |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
| reactome | R-HSA-9006921 | Integrin signaling |
| reactome | R-HSA-977225 | Amyloid fiber formation |
| biocarta | extrinsicpathway | extrinsic prothrombin activation pathway |
| biocarta | fibrinolysispathway | fibrinolysis pathway |
| biocarta | intrinsicpathway | intrinsic prothrombin activation pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FGA
CLASSFICATION
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