SIRT2
Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sirtuin 2 | MIM:604480 | Ensembl:ENSG00000068903 | HGNC:HGNC:10886 | PA35786 | 19q13.2 |
GO terms in SIRT2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003682 | chromatin binding |
| MF | TAS | GO:0003950 | NAD+ ADP-ribosyltransferase activity |
| MF | IDA | GO:0004407 | histone deacetylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IDA | GO:0017136 | NAD-dependent histone deacetylase activity |
| MF | IDA | GO:0033558 | protein deacetylase activity |
| MF | IMP | GO:0033558 | protein deacetylase activity |
| MF | IDA | GO:0034979 | NAD-dependent protein deacetylase activity |
| MF | IMP | GO:0034979 | NAD-dependent protein deacetylase activity |
| MF | IPI | GO:0035035 | histone acetyltransferase binding |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | IDA | GO:0042903 | tubulin deacetylase activity |
| MF | IDA | GO:0043130 | ubiquitin binding |
| MF | IDA | GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific) |
| MF | IDA | GO:0070403 | NAD+ binding |
| CC | IEA | GO:0000781 | chromosome, telomeric region |
| CC | IDA | GO:0005634 | nucleus |
| CC | NAS | GO:0005677 | chromatin silencing complex |
| CC | IDA | GO:0005694 | chromosome |
| CC | ISS | GO:0005720 | nuclear heterochromatin |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005814 | centriole |
| CC | IDA | GO:0005819 | spindle |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005874 | microtubule |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0030426 | growth cone |
| CC | IDA | GO:0030496 | midbody |
| CC | ISS | GO:0033010 | paranodal junction |
| CC | ISS | GO:0033270 | paranode region of axon |
| CC | ISS | GO:0043204 | perikaryon |
| CC | ISS | GO:0043209 | myelin sheath |
| CC | ISS | GO:0043219 | lateral loop |
| CC | ISS | GO:0043220 | Schmidt-Lanterman incisure |
| CC | ISS | GO:0044224 | juxtaparanode region of axon |
| CC | ISS | GO:0048471 | perinuclear region of cytoplasm |
| CC | IDA | GO:0072686 | mitotic spindle |
| CC | ISS | GO:0072687 | meiotic spindle |
| CC | ISS | GO:0097386 | glial cell projection |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | NAS | GO:0000183 | chromatin silencing at rDNA |
| BP | NAS | GO:0006342 | chromatin silencing |
| BP | NAS | GO:0006348 | chromatin silencing at telomere |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | NAS | GO:0006471 | protein ADP-ribosylation |
| BP | TAS | GO:0006471 | protein ADP-ribosylation |
| BP | IDA | GO:0006476 | protein deacetylation |
| BP | IMP | GO:0006476 | protein deacetylation |
| BP | IEA | GO:0006914 | autophagy |
| BP | NAS | GO:0007096 | regulation of exit from mitosis |
| BP | IMP | GO:0008285 | negative regulation of cell proliferation |
| BP | IMP | GO:0010507 | negative regulation of autophagy |
| BP | ISS | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation |
| BP | IMP | GO:0014065 | phosphatidylinositol 3-kinase signaling |
| BP | NAS | GO:0016458 | gene silencing |
| BP | TAS | GO:0016575 | histone deacetylation |
| BP | HEP | GO:0021762 | substantia nigra development |
| BP | ISS | GO:0022011 | myelination in peripheral nervous system |
| BP | ISS | GO:0031641 | regulation of myelination |
| BP | ISS | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | ISS | GO:0034599 | cellular response to oxidative stress |
| BP | IDA | GO:0034983 | peptidyl-lysine deacetylation |
| BP | IDA | GO:0035729 | cellular response to hepatocyte growth factor stimulus |
| BP | IMP | GO:0042177 | negative regulation of protein catabolic process |
| BP | NAS | GO:0042325 | regulation of phosphorylation |
| BP | IMP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | ISS | GO:0043388 | positive regulation of DNA binding |
| BP | IMP | GO:0043491 | protein kinase B signaling |
| BP | ISS | GO:0044242 | cellular lipid catabolic process |
| BP | IEA | GO:0045087 | innate immune response |
| BP | ISS | GO:0045599 | negative regulation of fat cell differentiation |
| BP | ISS | GO:0045836 | positive regulation of meiotic nuclear division |
| BP | IDA | GO:0045843 | negative regulation of striated muscle tissue development |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0048012 | hepatocyte growth factor receptor signaling pathway |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:0051321 | meiotic cell cycle |
| BP | IMP | GO:0051726 | regulation of cell cycle |
| BP | NAS | GO:0051775 | response to redox state |
| BP | ISS | GO:0051781 | positive regulation of cell division |
| BP | ISS | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore |
| BP | IMP | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| BP | ISS | GO:0061433 | cellular response to caloric restriction |
| BP | ISS | GO:0070446 | negative regulation of oligodendrocyte progenitor proliferation |
| BP | IMP | GO:0070932 | histone H3 deacetylation |
| BP | IDA | GO:0070933 | histone H4 deacetylation |
| BP | IDA | GO:0071219 | cellular response to molecule of bacterial origin |
| BP | IDA | GO:0071456 | cellular response to hypoxia |
| BP | ISS | GO:0071872 | cellular response to epinephrine stimulus |
| BP | IDA | GO:0090042 | tubulin deacetylation |
| BP | IMP | GO:0090042 | tubulin deacetylation |
| BP | ISS | GO:0090042 | tubulin deacetylation |
| BP | ISS | GO:1900119 | positive regulation of execution phase of apoptosis |
| BP | ISS | GO:1900195 | positive regulation of oocyte maturation |
| BP | IEA | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly |
| BP | IMP | GO:1900425 | negative regulation of defense response to bacterium |
| BP | ISS | GO:2000378 | negative regulation of reactive oxygen species metabolic process |
| BP | IMP | GO:2000777 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia |
Gene expression in normal tissue: SIRT2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SIRT2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | hdac_classiii_pathway | Signaling events mediated by HDAC Class III |
| wikipathways | WP3644 | NAD+ metabolism |
| wikipathways | WP3645 | NAD+ biosynthetic pathways |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SIRT2
CLASSFICATION
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