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LARP4B

Summary: This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. [provided by RefSeq, Oct 2012].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
La ribonucleoprotein domain family member 4B	MIM:616513	Ensembl:ENSG00000107929	HGNC:HGNC:28987	PA165548762	10p15.3

GO terms in LARP4B

Term Type	Evidence Type	GO Term ID	GO Des.
MF	HDA	GO:0003723	RNA binding
MF	IPI	GO:0005515	protein binding
CC	IDA	GO:0005730	nucleolus
CC	IDA	GO:0005829	cytosol
CC	IDA	GO:0010494	cytoplasmic stress granule
CC	HDA	GO:0016020	membrane
CC	IDA	GO:0042788	polysomal ribosome
BP	IMP	GO:0045727	positive regulation of translation

Gene expression in normal tissue: LARP4B

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LARP4B

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD403	BAY 61-3606	1
iGMDRD778	SCHEMBL13586708	1
iGMDRD363	OSI-930	1
iGMDRD185	DMOG	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LARP4B

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DATATYPES

CLASSFICATION

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