LARP4B


Summary: This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. [provided by RefSeq, Oct 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
La ribonucleoprotein domain family member 4BMIM:616513Ensembl:ENSG00000107929HGNC:HGNC:28987PA16554876210p15.3

GO terms in LARP4B


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
CCIDAGO:0005730nucleolus
CCIDAGO:0005829cytosol
CCIDAGO:0010494cytoplasmic stress granule
CCHDAGO:0016020membrane
CCIDAGO:0042788polysomal ribosome
BPIMPGO:0045727positive regulation of translation

Gene expression in normal tissue: LARP4B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LARP4B


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD403BAY 61-36061
iGMDRD778SCHEMBL135867081
iGMDRD363OSI-9301
iGMDRD185DMOG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LARP4B

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