PHLPP1
Summary: This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:609396 Ensembl IDEnsembl:ENSG00000081913 HGNC IDHGNC:HGNC:20610 PHARMGKB IDPA165429055 Map Location18q21.33 |
Gene Categories:
PROTEIN PHOSPHATASEGO terms in PHLPP1
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IBA | GO:0001917 | photoreceptor inner segment |
CC | IBA | GO:0005737 | cytoplasm |
CC | TAS | GO:0005829 | cytosol |
CC | IBA | GO:0031965 | nuclear membrane |
CC | IBA | GO:0042622 | photoreceptor outer segment membrane |
BP | IEA | GO:0002667 | regulation of T cell anergy |
Gene expression in normal tissue: PHLPP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PHLPP1
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
netpath | Pathway_EGFR1 | EGFR1 |
kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
reactome | R-HSA-162582 | Signal Transduction |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PHLPP1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |