PHLPP1

Summary: This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NamePH domain and leucine rich repeat protein phosphatase 1
OMIM IDMIM:609396
Ensembl IDEnsembl:ENSG00000081913
HGNC IDHGNC:HGNC:20610
PHARMGKB IDPA165429055
Map Location18q21.33

Gene Categories:

PROTEIN PHOSPHATASE

GO terms in PHLPP1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0001917 photoreceptor inner segment
CC IBA GO:0005737 cytoplasm
CC TAS GO:0005829 cytosol
CC IBA GO:0031965 nuclear membrane
CC IBA GO:0042622 photoreceptor outer segment membrane
BP IEA GO:0002667 regulation of T cell anergy
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Gene expression in normal tissue: PHLPP1

Gene-model tissue-cancer distribution: Bubble Plot

LIVEtissue: LIVE cancer: LIVER model num: 0LIVERtissue: LIVER cancer: Hepatocellular Carcinoma (HCC) model num: 2

Gene-drug pathway distribution

undefined1WNT signaling1

Pathways in PHLPP1


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Database
Pathway ID
Pathway Des.
wikipathways WP3932 Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways WP4172 PI3K-Akt Signaling Pathway
netpath Pathway_EGFR1 EGFR1
kegg hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
reactome R-HSA-1257604 PIP3 activates AKT signaling
reactome R-HSA-162582 Signal Transduction
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD245 FH535 1
iGMDRD593 CX-5461 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PHLPP1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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