PHLPP1
Summary: This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| PH domain and leucine rich repeat protein phosphatase 1 | MIM:609396 | Ensembl:ENSG00000081913 | HGNC:HGNC:20610 | PA165429055 | 18q21.33 |
Gene Categories:
PROTEIN PHOSPHATASEGO terms in PHLPP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0001917 | photoreceptor inner segment |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0031965 | nuclear membrane |
| CC | IBA | GO:0042622 | photoreceptor outer segment membrane |
| BP | IEA | GO:0002667 | regulation of T cell anergy |
| BP | IBA | GO:0006470 | protein dephosphorylation |
| BP | IEA | GO:0006470 | protein dephosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0009649 | entrainment of circadian clock |
| BP | IDA | GO:0042981 | regulation of apoptotic process |
| BP | IMP | GO:0043408 | regulation of MAPK cascade |
| BP | IBA | GO:0046328 | regulation of JNK cascade |
| BP | IDA | GO:0046328 | regulation of JNK cascade |
| BP | IBA | GO:0051896 | regulation of protein kinase B signaling |
| BP | IMP | GO:0051898 | negative regulation of protein kinase B signaling |
| BP | IBA | GO:0090036 | regulation of protein kinase C signaling |
| BP | IBA | GO:1900744 | regulation of p38MAPK cascade |
| BP | IDA | GO:1900744 | regulation of p38MAPK cascade |
| MF | IBA | GO:0004722 | protein serine/threonine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: PHLPP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PHLPP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PHLPP1
CLASSFICATION
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