MCF2L
Summary: This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:609499 Ensembl IDEnsembl:ENSG00000126217 HGNC IDHGNC:HGNC:14576 PHARMGKB IDPA30685 Map Location13q34 | |||||
GO terms in MCF2L
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | HDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0012505 | endomembrane system |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0035023 | regulation of Rho protein signal transduction |
Gene expression in normal tissue: MCF2L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MCF2L
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cdc42_reg_pathway | Regulation of CDC42 activity |
| pid | rhoa_reg_pathway | Regulation of RhoA activity |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD491 | TAE-684 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MCF2L
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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