CLCF1
Summary: This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cardiotrophin like cytokine factor 1 | MIM:607672 | Ensembl:ENSG00000175505 | HGNC:HGNC:17412 | PA142672106 | 11q13.2 |
GO terms in CLCF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0002639 | positive regulation of immunoglobulin production |
| BP | IBA | GO:0007166 | cell surface receptor signaling pathway |
| BP | ISS | GO:0007166 | cell surface receptor signaling pathway |
| BP | ISS | GO:0007259 | JAK-STAT cascade |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | NAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | ISS | GO:0030183 | B cell differentiation |
| BP | IBA | GO:0030890 | positive regulation of B cell proliferation |
| BP | ISS | GO:0030890 | positive regulation of B cell proliferation |
| BP | IDA | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | TAS | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | IDA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | ISS | GO:0048295 | positive regulation of isotype switching to IgE isotypes |
| BP | ISS | GO:0048711 | positive regulation of astrocyte differentiation |
| CC | IBA | GO:0005576 | extracellular region |
| CC | IDA | GO:0005576 | extracellular region |
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005622 | intracellular |
| CC | IBA | GO:0097058 | CRLF-CLCF1 complex |
| CC | IDA | GO:0097058 | CRLF-CLCF1 complex |
| CC | IBA | GO:0097059 | CNTFR-CLCF1 complex |
| CC | IDA | GO:0097059 | CNTFR-CLCF1 complex |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IBA | GO:0005125 | cytokine activity |
| MF | IDA | GO:0005125 | cytokine activity |
| MF | NAS | GO:0005125 | cytokine activity |
| MF | IDA | GO:0005127 | ciliary neurotrophic factor receptor binding |
| MF | IDA | GO:0005127 | ciliary neurotrophic factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008083 | growth factor activity |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: CLCF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CLCF1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6783589 | Interleukin-6 family signaling |
| reactome | R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CLCF1
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