CBLC
Summary: This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:608453 Ensembl IDEnsembl:ENSG00000142273 HGNC IDHGNC:HGNC:15961 PHARMGKB IDPA26117 Map Location19q13.32 |
GO terms in CBLC
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IDA | GO:0006511 | ubiquitin-dependent protein catabolic process |
BP | IBA | GO:0007165 | signal transduction |
BP | IEA | GO:0007166 | cell surface receptor signaling pathway |
BP | IBA | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity |
BP | IDA | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity |
BP | IDA | GO:0016567 | protein ubiquitination |
Gene expression in normal tissue: CBLC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CBLC
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
wikipathways | WP437 | EGF-EGFR Signaling Pathway |
wikipathways | WP481 | Insulin Signaling |
wikipathways | WP673 | ErbB Signaling Pathway |
netpath | Pathway_EGFR1 | EGFR1 |
kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD532 | Olaparib | 1 |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in CBLC
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |