CBLC


Summary: This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:608453
PHARMGKB IDPA26117
Map Location19q13.32

GO terms in CBLC


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0006511 ubiquitin-dependent protein catabolic process
BP IBA GO:0007165 signal transduction
BP IEA GO:0007166 cell surface receptor signaling pathway
BP IBA GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
BP IDA GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
BP IDA GO:0016567 protein ubiquitination
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Gene expression in normal tissue: CBLC

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CBLC


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Database
Pathway ID
Pathway Des.
wikipathways WP3915 Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways WP437 EGF-EGFR Signaling Pathway
wikipathways WP481 Insulin Signaling
wikipathways WP673 ErbB Signaling Pathway
netpath Pathway_EGFR1 EGFR1
kegg hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD532 Olaparib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CBLC

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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