Summary: This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].

Cbl proto-oncogene CMIM:608453Ensembl:ENSG00000142273HGNC:HGNC:15961PA2611719q13.32

GO terms in CBLC

Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0006511ubiquitin-dependent protein catabolic process
BPIBAGO:0007165signal transduction
BPIEAGO:0007166cell surface receptor signaling pathway
BPIBAGO:0007175negative regulation of epidermal growth factor-activated receptor activity
BPIDAGO:0007175negative regulation of epidermal growth factor-activated receptor activity
BPIDAGO:0016567protein ubiquitination
BPIDAGO:0042059negative regulation of epidermal growth factor receptor signaling pathway
BPIDAGO:0043407negative regulation of MAP kinase activity
CCIBAGO:0005886plasma membrane
CCIBAGO:0045121membrane raft
MFIDAGO:0001784phosphotyrosine residue binding
MFIDAGO:0005154epidermal growth factor receptor binding
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFTASGO:0008270zinc ion binding
MFIBAGO:0017124SH3 domain binding
MFIDAGO:0017124SH3 domain binding
MFIBAGO:0030971receptor tyrosine kinase binding
MFIBAGO:0061630ubiquitin protein ligase activity
MFIDAGO:0061630ubiquitin protein ligase activity

Gene expression in normal tissue: CBLC

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CBLC

DatabasePathway IDPathway Des.
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP673ErbB Signaling Pathway
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CBLC