CBLC
Summary: This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Cbl proto-oncogene C | MIM:608453 | Ensembl:ENSG00000142273 | HGNC:HGNC:15961 | PA26117 | 19q13.32 |
GO terms in CBLC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IBA | GO:0007165 | signal transduction |
| BP | IEA | GO:0007166 | cell surface receptor signaling pathway |
| BP | IBA | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity |
| BP | IDA | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | IDA | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| BP | IDA | GO:0043407 | negative regulation of MAP kinase activity |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0045121 | membrane raft |
| MF | IDA | GO:0001784 | phosphotyrosine residue binding |
| MF | IDA | GO:0005154 | epidermal growth factor receptor binding |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008270 | zinc ion binding |
| MF | IBA | GO:0017124 | SH3 domain binding |
| MF | IDA | GO:0017124 | SH3 domain binding |
| MF | IBA | GO:0030971 | receptor tyrosine kinase binding |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
| MF | IDA | GO:0061630 | ubiquitin protein ligase activity |
Gene expression in normal tissue: CBLC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CBLC
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP673 | ErbB Signaling Pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CBLC
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.