NR6A1


Summary: This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in NR6A1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP ISS GO:0000122 negative regulation of transcription by RNA polymerase II
BP IBA GO:0006355 regulation of transcription, DNA-templated
BP TAS GO:0006367 transcription initiation from RNA polymerase II promoter
BP ISS GO:0007276 gamete generation
BP TAS GO:0007283 spermatogenesis
BP TAS GO:0008283 cell proliferation
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Gene expression in normal tissue: NR6A1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NR6A1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-212436 Generic Transcription Pathway
reactome R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
reactome R-HSA-383280 Nuclear Receptor transcription pathway
reactome R-HSA-452723 Transcriptional regulation of pluripotent stem cells
reactome R-HSA-73857 RNA Polymerase II Transcription
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD536 PLX-4720 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NR6A1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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