NR6A1
Summary: This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:602778 Ensembl IDEnsembl:ENSG00000148200 HGNC IDHGNC:HGNC:7985 PHARMGKB IDPA31766 Map Location9q33.3 |
GO terms in NR6A1
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
BP | IBA | GO:0006355 | regulation of transcription, DNA-templated |
BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
BP | ISS | GO:0007276 | gamete generation |
BP | TAS | GO:0007283 | spermatogenesis |
BP | TAS | GO:0008283 | cell proliferation |
Gene expression in normal tissue: NR6A1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NR6A1
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-212436 | Generic Transcription Pathway |
reactome | R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation |
reactome | R-HSA-383280 | Nuclear Receptor transcription pathway |
reactome | R-HSA-452723 | Transcriptional regulation of pluripotent stem cells |
reactome | R-HSA-73857 | RNA Polymerase II Transcription |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD536 | PLX-4720 | 1 |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in NR6A1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |