TNFRSF21
Summary: This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF receptor superfamily member 21 | MIM:605732 | Ensembl:ENSG00000146072 | HGNC:HGNC:13469 | PA37775 | 6p12.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in TNFRSF21
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0030424 | axon |
| CC | ISS | GO:0031226 | intrinsic component of plasma membrane |
| BP | ISS | GO:0001783 | B cell apoptotic process |
| BP | ISS | GO:0002250 | adaptive immune response |
| BP | IMP | GO:0006915 | apoptotic process |
| BP | ISS | GO:0006959 | humoral immune response |
| BP | TAS | GO:0019216 | regulation of lipid metabolic process |
| BP | ISS | GO:0030889 | negative regulation of B cell proliferation |
| BP | IBA | GO:0031642 | negative regulation of myelination |
| BP | IMP | GO:0031642 | negative regulation of myelination |
| BP | IEA | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | ISS | GO:0042130 | negative regulation of T cell proliferation |
| BP | ISS | GO:0042552 | myelination |
| BP | IBA | GO:0048713 | regulation of oligodendrocyte differentiation |
| BP | ISS | GO:0048713 | regulation of oligodendrocyte differentiation |
| BP | ISS | GO:0050852 | T cell receptor signaling pathway |
| BP | ISS | GO:0051402 | neuron apoptotic process |
| BP | IDA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | ISS | GO:0097252 | oligodendrocyte apoptotic process |
| BP | ISS | GO:2000663 | negative regulation of interleukin-5 secretion |
| BP | ISS | GO:2000666 | negative regulation of interleukin-13 secretion |
| BP | ISS | GO:2001180 | negative regulation of interleukin-10 secretion |
Gene expression in normal tissue: TNFRSF21
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF21
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2797 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP3395 | Cellular response to heat stress |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF21
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