DDX25


Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DEAD-box helicase 25MIM:607663Ensembl:ENSG00000109832HGNC:HGNC:18698PA3864411q24.2

GO terms in DDX25


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003723RNA binding
MFISSGO:0004004ATP-dependent RNA helicase activity
MFISSGO:0005524ATP binding
BPISSGO:0006406mRNA export from nucleus
BPISSGO:0006417regulation of translation
BPIEAGO:0007275multicellular organism development
BPISSGO:0007286spermatid development
CCISSGO:0005634nucleus
CCISSGO:0005737cytoplasm
CCISSGO:0033391chromatoid body

Gene expression in normal tissue: DDX25

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DDX25


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD536PLX-47201
iGMDRD30917AAG1
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DDX25

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