TMOD2
Summary: This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nametropomodulin 2 OMIM IDMIM:602928 Ensembl IDEnsembl:ENSG00000128872 HGNC IDHGNC:HGNC:11872 PHARMGKB IDPA36573 Map Location15q21.2 | |||||
GO terms in TMOD2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003779 | actin binding |
| MF | IBA | GO:0005523 | tropomyosin binding |
| CC | IBA | GO:0005856 | cytoskeleton |
| CC | IBA | GO:0005865 | striated muscle thin filament |
| CC | IBA | GO:0030016 | myofibril |
| CC | IEA | GO:0030426 | growth cone |
Gene expression in normal tissue: TMOD2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TMOD2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-390522 | Striated Muscle Contraction |
| reactome | R-HSA-397014 | Muscle contraction |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TMOD2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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