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TMOD2

Summary: This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
tropomodulin 2	MIM:602928	Ensembl:ENSG00000128872	HGNC:HGNC:11872	PA36573	15q21.2

GO terms in TMOD2

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0003779	actin binding
MF	IBA	GO:0005523	tropomyosin binding
CC	IBA	GO:0005856	cytoskeleton
CC	IBA	GO:0005865	striated muscle thin filament
CC	IBA	GO:0030016	myofibril
CC	IEA	GO:0030426	growth cone
BP	IBA	GO:0006936	muscle contraction
BP	IBA	GO:0007015	actin filament organization
BP	IEA	GO:0007270	neuron-neuron synaptic transmission
BP	TAS	GO:0007399	nervous system development
BP	IEA	GO:0007611	learning or memory
BP	IBA	GO:0030239	myofibril assembly
BP	IEA	GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
BP	IEA	GO:0051694	pointed-end actin filament capping

Gene expression in normal tissue: TMOD2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TMOD2

Database	Pathway ID	Pathway Des.
reactome	R-HSA-390522	Striated Muscle Contraction
reactome	R-HSA-397014	Muscle contraction

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD491	TAE-684	1
iGMDRD309	17AAG	2
iGMDRD68	Paclitaxel	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TMOD2

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DATATYPES

CLASSFICATION

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