HLA-DRA
Summary: HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:142860 Ensembl IDEnsembl:ENSG00000204287 HGNC IDHGNC:HGNC:4947 PHARMGKB IDPA35071 Map Location6p21.32 | |||||
GO terms in HLA-DRA
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005764 | lysosome |
| CC | IDA | GO:0005765 | lysosomal membrane |
| CC | TAS | GO:0005765 | lysosomal membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
Gene expression in normal tissue: HLA-DRA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HLA-DRA
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| biocarta | ctla4pathway | the co-stimulatory signal during t-cell activation |
| biocarta | il4pathway | il 4 signaling pathway |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| biocarta | mhcpathway | antigen processing and presentation |
| biocarta | tcrapathway | lck and fyn tyrosine kinases in initiation of tcr activation |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HLA-DRA
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.