HLA-DRA
Summary: HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| major histocompatibility complex, class II, DR alpha | MIM:142860 | Ensembl:ENSG00000204287 | HGNC:HGNC:4947 | PA35071 | 6p21.32 |
GO terms in HLA-DRA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005764 | lysosome |
| CC | IDA | GO:0005765 | lysosomal membrane |
| CC | TAS | GO:0005765 | lysosomal membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | NAS | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | TAS | GO:0012507 | ER to Golgi transport vesicle membrane |
| CC | TAS | GO:0030658 | transport vesicle membrane |
| CC | TAS | GO:0030666 | endocytic vesicle membrane |
| CC | TAS | GO:0030669 | clathrin-coated endocytic vesicle membrane |
| CC | IDA | GO:0031902 | late endosome membrane |
| CC | TAS | GO:0032588 | trans-Golgi network membrane |
| CC | IDA | GO:0042613 | MHC class II protein complex |
| CC | IMP | GO:0042613 | MHC class II protein complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:0071556 | integral component of lumenal side of endoplasmic reticulum membrane |
| BP | IDA | GO:0002503 | peptide antigen assembly with MHC class II protein complex |
| BP | IDA | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| BP | IDA | GO:0002506 | polysaccharide assembly with MHC class II protein complex |
| BP | NAS | GO:0006955 | immune response |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | IMP | GO:0050890 | cognition |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| MF | IPI | GO:0005515 | protein binding |
| MF | HDA | GO:0023026 | MHC class II protein complex binding |
| MF | NAS | GO:0032395 | MHC class II receptor activity |
| MF | IDA | GO:0042605 | peptide antigen binding |
Gene expression in normal tissue: HLA-DRA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HLA-DRA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| biocarta | ctla4pathway | the co-stimulatory signal during t-cell activation |
| biocarta | il4pathway | il 4 signaling pathway |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| biocarta | mhcpathway | antigen processing and presentation |
| biocarta | tcrapathway | lck and fyn tyrosine kinases in initiation of tcr activation |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains |
| reactome | R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse |
| reactome | R-HSA-202433 | Generation of second messenger molecules |
| reactome | R-HSA-2132295 | MHC class II antigen presentation |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389948 | PD-1 signaling |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP4141 | PI3K-AKT-mTOR - VitD3 Signalling |
| wikipathways | WP530 | Cytokines and Inflammatory Response |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| kegg | hsa04612 | Antigen processing and presentation - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04672 | Intestinal immune network for IgA production - Homo sapiens (human) |
| kegg | hsa04940 | Type I diabetes mellitus - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05150 | Staphylococcus aureus infection - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05310 | Asthma - Homo sapiens (human) |
| kegg | hsa05320 | Autoimmune thyroid disease - Homo sapiens (human) |
| kegg | hsa05321 | Inflammatory bowel disease (IBD) - Homo sapiens (human) |
| kegg | hsa05322 | Systemic lupus erythematosus - Homo sapiens (human) |
| kegg | hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| kegg | hsa05330 | Allograft rejection - Homo sapiens (human) |
| kegg | hsa05332 | Graft-versus-host disease - Homo sapiens (human) |
| kegg | hsa05416 | Viral myocarditis - Homo sapiens (human) |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il12_stat4pathway | IL12 signaling mediated by STAT4 |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD955 | Nivolumab | 1 |
| iGMDRD978 | Pembrolizumab | 1 |
| iGMDRD824 | Atezolizumab | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HLA-DRA
CLASSFICATION
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