iGMDRD955

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Standard Name
DRUGBANK ID
Drug Status
Drug Type
Standard NameNivolumab
DRUGBANK IDDB09035
Drug StatusAlone
Drug TypeBiotech

Drug Targets:

PDCD1 (Q15116)

Drug-model tissue-cancer distribution: Bubble Plot

KIDNEtissue: KIDNE cancer: KIDNEY model num: 0KIDNEYtissue: KIDNEY cancer: Renal Cell Carcinoma (RCC) model num: 1SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Melanoma (MEL) model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Non-Small Cell Lung Cancer (NSCLC) model num: 2BRAItissue: BRAI cancer: BRAIN model num: 0BRAINtissue: BRAIN cancer: Glioblastoma Multiforme (GBM) model num: 1OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 1

Drug-gene pathway enrichments

2kegg: Cell adhesion molecules (CAMs) - Homo sapiens (human)2reactome: DNA Repair2reactome: Immune System2reactome: Costimulation by the CD28 family2reactome: PD-1 signaling2reactome: Mismatch Repair2reactome: Adaptive Immune System1kegg: Leishmaniasis - Homo sapiens (human)1kegg: Type I diabetes mellitus - Homo sapiens (human)1kegg: Toxoplasmosis - Homo sapiens (human)

Drug-gene GO enrichments

5CC: plasma membrane4BP: mismatch repair3BP: immune response3BP: T cell costimulation3MF: protein binding2CC: MHC class II protein complex2CC: extracellular exosome2CC: cell surface2BP: signal transduction2BP: positive regulation of T cell proliferation

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
29126 CD274 6
3122 HLA-DRA 1
5395 PMS2 1
Showing 1 to 3 of 3 rows

Gene in drug-gene network: Network Plot

Models in Nivolumab

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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