HMGCS1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-CoA synthase 1 | MIM:142940 | Ensembl:ENSG00000112972 | HGNC:HGNC:5007 | PA29337 | 5p12 |
GO terms in HMGCS1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IEA | GO:0001889 | liver development |
| BP | IBA | GO:0006084 | acetyl-CoA metabolic process |
| BP | NAS | GO:0006629 | lipid metabolic process |
| BP | TAS | GO:0006695 | cholesterol biosynthetic process |
| BP | IEA | GO:0007420 | brain development |
| BP | IEA | GO:0008299 | isoprenoid biosynthetic process |
| BP | IEA | GO:0008584 | male gonad development |
| BP | IEA | GO:0009645 | response to low light intensity stimulus |
| BP | IBA | GO:0010142 | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| BP | IEA | GO:0014074 | response to purine-containing compound |
| BP | TAS | GO:0019216 | regulation of lipid metabolic process |
| BP | IEA | GO:0033197 | response to vitamin E |
| BP | IEA | GO:0042493 | response to drug |
| BP | TAS | GO:0045540 | regulation of cholesterol biosynthetic process |
| BP | IEA | GO:0046690 | response to tellurium ion |
| BP | IEA | GO:0071372 | cellular response to follicle-stimulating hormone stimulus |
| BP | IEA | GO:0071397 | cellular response to cholesterol |
| BP | IEA | GO:0071404 | cellular response to low-density lipoprotein particle stimulus |
| MF | IBA | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity |
| MF | TAS | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity |
| MF | IEA | GO:0008144 | drug binding |
| MF | IEA | GO:0016853 | isomerase activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0043177 | organic acid binding |
Gene expression in normal tissue: HMGCS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HMGCS1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PWY-5910 | superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) |
| humancyc | PWY-922 | mevalonate pathway |
| humancyc | PWY66-367 | ketogenesis |
| humancyc | PWY66-5 | superpathway of cholesterol biosynthesis |
| kegg | hsa00072 | Synthesis and degradation of ketone bodies - Homo sapiens (human) |
| kegg | hsa00280 | Valine, leucine and isoleucine degradation - Homo sapiens (human) |
| kegg | hsa00650 | Butanoate metabolism - Homo sapiens (human) |
| kegg | hsa00900 | Terpenoid backbone biosynthesis - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| reactome | R-HSA-191273 | Cholesterol biosynthesis |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8957322 | Metabolism of steroids |
| biocarta | s1ppathway | srebp control of lipid synthesis |
| pharmgkb | PA154423660 | Bisphosphonate Pathway, Pharmacodynamics |
| pid | hnf3bpathway | FOXA2 and FOXA3 transcription factor networks |
| smpdb | SMP00023 | Steroid Biosynthesis |
| smpdb | SMP00079 | Ibandronate Action Pathway |
| smpdb | SMP00082 | Simvastatin Action Pathway |
| smpdb | SMP00089 | Pravastatin Action Pathway |
| smpdb | SMP00092 | Rosuvastatin Action Pathway |
| smpdb | SMP00095 | Alendronate Action Pathway |
| smpdb | SMP00099 | Lovastatin Action Pathway |
| smpdb | SMP00107 | Zoledronate Action Pathway |
| smpdb | SMP00111 | Cerivastatin Action Pathway |
| smpdb | SMP00112 | Risedronate Action Pathway |
| smpdb | SMP00117 | Pamidronate Action Pathway |
| smpdb | SMP00119 | Fluvastatin Action Pathway |
| smpdb | SMP00131 | Atorvastatin Action Pathway |
| smpdb | SMP00209 | Hypercholesterolemia |
| smpdb | SMP00319 | Lysosomal Acid Lipase Deficiency (Wolman Disease) |
| smpdb | SMP00386 | Desmosterolosis |
| smpdb | SMP00387 | CHILD Syndrome |
| smpdb | SMP00388 | Chondrodysplasia Punctata II, X Linked Dominant (CDPX2) |
| smpdb | SMP00389 | Smith-Lemli-Opitz Syndrome (SLOS) |
| smpdb | SMP00508 | Cholesteryl ester storage disease |
| smpdb | SMP00509 | Hyper-IgD syndrome |
| smpdb | SMP00510 | Mevalonic aciduria |
| smpdb | SMP00511 | Wolman disease |
| wikipathways | WP197 | Cholesterol Biosynthesis |
| wikipathways | WP1982 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| wikipathways | WP2011 | SREBF and miR33 in cholesterol and lipid homeostasis |
| wikipathways | WP2706 | Activation of gene expression by SREBF (SREBP) |
| wikipathways | WP2797 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| wikipathways | WP3963 | Mevalonate pathway |
| wikipathways | WP474 | Endochondral Ossification |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HMGCS1
CLASSFICATION
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