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FOXA1

Summary: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameforkhead box A1 OMIM IDMIM:602294 Ensembl IDEnsembl:ENSG00000129514 HGNC IDHGNC:HGNC:5021 PHARMGKB IDPA201090 Map Location14q21.1

Gene Categories:

CLINICALLY ACTIONABLE TUMOR SUPPRESSOR TRANSCRIPTION FACTOR BINDING

GO terms in FOXA1

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISS	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IDA	GO:0003677	DNA binding

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Gene expression in normal tissue: FOXA1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FOXA1

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Database	Pathway ID	Pathway Des.
wikipathways	WP2263	Androgen Receptor Network in Prostate Cancer
wikipathways	WP2853	Endoderm Differentiation
wikipathways	WP2857	Mesodermal Commitment Pathway
wikipathways	WP3932	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
netpath	Pathway_AndrogenReceptor	AndrogenReceptor
pid	hnf3apathway	FOXA1 transcription factor network

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD832	BCL2 inhibitor	2
iGMDRD536	PLX-4720	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOXA1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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