Summary: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008].

forkhead box A1MIM:602294Ensembl:ENSG00000129514HGNC:HGNC:5021PA20109014q21.1

GO terms in FOXA1

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISSGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008134transcription factor binding
MFIEAGO:0019904protein domain specific binding
MFIEAGO:0043565sequence-specific DNA binding
MFIDAGO:0044212transcription regulatory region DNA binding
CCIDAGO:0001650fibrillar center
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0006338chromatin remodeling
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006366transcription by RNA polymerase II
BPIEAGO:0007219Notch signaling pathway
BPIBAGO:0009653anatomical structure morphogenesis
BPIMPGO:0010719negative regulation of epithelial to mesenchymal transition
BPIEAGO:0021904dorsal/ventral neural tube patterning
BPIBAGO:0030154cell differentiation
BPIDAGO:0032355response to estradiol
BPIMPGO:0033148positive regulation of intracellular estrogen receptor signaling pathway
BPIEAGO:0042445hormone metabolic process
BPIEAGO:0042593glucose homeostasis
BPIDAGO:0043065positive regulation of apoptotic process
BPIEAGO:0045666positive regulation of neuron differentiation
BPIEAGO:0045880positive regulation of smoothened signaling pathway
BPIMPGO:0045931positive regulation of mitotic cell cycle
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048646anatomical structure formation involved in morphogenesis
BPIEAGO:0048665neuron fate specification
BPIMPGO:0051091positive regulation of DNA-binding transcription factor activity
BPIEAGO:0060441epithelial tube branching involved in lung morphogenesis
BPIEAGO:0060487lung epithelial cell differentiation
BPIEAGO:0060528secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
BPIEAGO:0060738epithelial-mesenchymal signaling involved in prostate gland development
BPIEAGO:0060740prostate gland epithelium morphogenesis
BPIEAGO:0060741prostate gland stromal morphogenesis
BPIEAGO:0060743epithelial cell maturation involved in prostate gland development
BPIEAGO:0061144alveolar secondary septum development
BPTASGO:0071542dopaminergic neuron differentiation
BPIEAGO:1902691respiratory basal cell differentiation
BPICGO:2000049positive regulation of cell-cell adhesion mediated by cadherin

Gene expression in normal tissue: FOXA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FOXA1

DatabasePathway IDPathway Des.
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP2853Endoderm Differentiation
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
pidhnf3apathwayFOXA1 transcription factor network
pidhnf3bpathwayFOXA2 and FOXA3 transcription factor networks
pidp53downstreampathwayDirect p53 effectors
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-8939211ESR-mediated signaling
reactomeR-HSA-9006931Signaling by Nuclear Receptors
reactomeR-HSA-9018519Estrogen-dependent gene expression

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD832BCL2 inhibitor2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOXA1