FOXA1
Summary: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| forkhead box A1 | MIM:602294 | Ensembl:ENSG00000129514 | HGNC:HGNC:5021 | PA201090 | 14q21.1 |
GO terms in FOXA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISS | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0019904 | protein domain specific binding |
| MF | IEA | GO:0043565 | sequence-specific DNA binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005902 | microvillus |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0006338 | chromatin remodeling |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0007219 | Notch signaling pathway |
| BP | IBA | GO:0009653 | anatomical structure morphogenesis |
| BP | IMP | GO:0010719 | negative regulation of epithelial to mesenchymal transition |
| BP | IEA | GO:0021904 | dorsal/ventral neural tube patterning |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0032355 | response to estradiol |
| BP | IMP | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway |
| BP | IEA | GO:0042445 | hormone metabolic process |
| BP | IEA | GO:0042593 | glucose homeostasis |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0045666 | positive regulation of neuron differentiation |
| BP | IEA | GO:0045880 | positive regulation of smoothened signaling pathway |
| BP | IMP | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048646 | anatomical structure formation involved in morphogenesis |
| BP | IEA | GO:0048665 | neuron fate specification |
| BP | IMP | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:0060441 | epithelial tube branching involved in lung morphogenesis |
| BP | IEA | GO:0060487 | lung epithelial cell differentiation |
| BP | IEA | GO:0060528 | secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development |
| BP | IEA | GO:0060738 | epithelial-mesenchymal signaling involved in prostate gland development |
| BP | IEA | GO:0060740 | prostate gland epithelium morphogenesis |
| BP | IEA | GO:0060741 | prostate gland stromal morphogenesis |
| BP | IEA | GO:0060743 | epithelial cell maturation involved in prostate gland development |
| BP | IEA | GO:0061144 | alveolar secondary septum development |
| BP | TAS | GO:0071542 | dopaminergic neuron differentiation |
| BP | IEA | GO:1902691 | respiratory basal cell differentiation |
| BP | IC | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin |
Gene expression in normal tissue: FOXA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOXA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP2853 | Endoderm Differentiation |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| pid | hnf3apathway | FOXA1 transcription factor network |
| pid | hnf3bpathway | FOXA2 and FOXA3 transcription factor networks |
| pid | p53downstreampathway | Direct p53 effectors |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FOXA1
CLASSFICATION
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