HTR7

Summary: The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Name5-hydroxytryptamine receptor 7
OMIM IDMIM:182137
Ensembl IDEnsembl:ENSG00000148680
HGNC IDHGNC:HGNC:5302
PHARMGKB IDPA29561
Map Location10q23.31

GO terms in HTR7


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005886 plasma membrane
CC IBA GO:0005887 integral component of plasma membrane
CC TAS GO:0005887 integral component of plasma membrane
CC IBA GO:0030425 dendrite
BP IEA GO:0006939 smooth muscle contraction
BP TAS GO:0007186 G-protein coupled receptor signaling pathway
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Gene expression in normal tissue: HTR7

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

Metabolic pathways1ERK MAPK signaling1

Pathways in HTR7


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Database
Pathway ID
Pathway Des.
pharmgkb PA161749006 Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics
kegg hsa04014 Ras signaling pathway - Homo sapiens (human)
kegg hsa04020 Calcium signaling pathway - Homo sapiens (human)
kegg hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegg hsa04726 Serotonergic synapse - Homo sapiens (human)
wikipathways WP117 GPCRs, Other
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD536 PLX-4720 1
iGMDRD68 Paclitaxel 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HTR7

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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