IREB2
Summary: The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| iron responsive element binding protein 2 | MIM:147582 | Ensembl:ENSG00000136381 | HGNC:HGNC:6115 | PA29914 | 15q25.1 |
GO terms in IREB2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006826 | iron ion transport |
| BP | TAS | GO:0006879 | cellular iron ion homeostasis |
| BP | IEA | GO:0008152 | metabolic process |
| BP | IEA | GO:0017148 | negative regulation of translation |
| CC | NAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| MF | IDA | GO:0003723 | RNA binding |
| MF | TAS | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0030350 | iron-responsive element binding |
| MF | IEA | GO:0030371 | translation repressor activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0051539 | 4 iron, 4 sulfur cluster binding |
Gene expression in normal tissue: IREB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IREB2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-917937 | Iron uptake and transport |
| wikipathways | WP2007 | Iron metabolism in placenta |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IREB2
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