JUP
Summary: This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:173325 Ensembl IDEnsembl:ENSG00000173801 HGNC IDHGNC:HGNC:6207 PHARMGKB IDPA30009 Map Location17q21.2 | |||||
GO terms in JUP
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | NAS | GO:0005198 | structural molecule activity |
| MF | IC | GO:0005199 | structural constituent of cell wall |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0019901 | protein kinase binding |
Gene expression in normal tissue: JUP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in JUP
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA2033 | Antiarrhythmic Pathway, Pharmacodynamics |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | ecadherin_keratinocyte_pathway | E-cadherin signaling in keratinocytes |
| pid | ecadherin_nascentaj_pathway | E-cadherin signaling in the nascent adherens junction |
| pid | ncadherinpathway | N-cadherin signaling events |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD409 | Saracatinib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in JUP
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.