Summary: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

potassium calcium-activated channel subfamily M alpha 1MIM:600150Ensembl:ENSG00000156113HGNC:HGNC:6284PA22010q22.3

GO terms in KCNMA1

Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0001666response to hypoxia
BPIDAGO:0006813potassium ion transport
BPIDAGO:0006970response to osmotic stress
BPIDAGO:0030007cellular potassium ion homeostasis
BPIDAGO:0034465response to carbon monoxide
BPIMPGO:0034465response to carbon monoxide
BPIEAGO:0034765regulation of ion transmembrane transport
BPIBAGO:0042391regulation of membrane potential
BPIDAGO:0042391regulation of membrane potential
BPIMPGO:0043065positive regulation of apoptotic process
BPIDAGO:0045794negative regulation of cell volume
BPIDAGO:0051592response to calcium ion
BPIDAGO:0060083smooth muscle contraction involved in micturition
BPIEAGO:0071805potassium ion transmembrane transport
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0008076voltage-gated potassium channel complex
CCIBAGO:0016021integral component of membrane
CCIDAGO:0016021integral component of membrane
CCIDAGO:0016324apical plasma membrane
CCIBAGO:0045211postsynaptic membrane
MFIDAGO:0003779actin binding
MFIDAGO:0005249voltage-gated potassium channel activity
MFIPIGO:0005515protein binding
MFIBAGO:0015269calcium-activated potassium channel activity
MFIDAGO:0015269calcium-activated potassium channel activity
MFIBAGO:0015271outward rectifier potassium channel activity
MFIEAGO:0046872metal ion binding
MFIBAGO:0060072large conductance calcium-activated potassium channel activity
MFIDAGO:0060072large conductance calcium-activated potassium channel activity
MFIMPGO:0060072large conductance calcium-activated potassium channel activity

Gene expression in normal tissue: KCNMA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNMA1

DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296052Ca2+ activated K+ channels
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-392154Nitric oxide stimulates guanylate cyclase
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418457cGMP effects
wikipathwaysWP4148Splicing factor NOVA regulated synaptic proteins
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04924Renin secretion - Homo sapiens (human)
kegghsa04970Salivary secretion - Homo sapiens (human)
kegghsa04972Pancreatic secretion - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNMA1