KCNMA1


Summary: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

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GO terms in KCNMA1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0001666 response to hypoxia
BP IDA GO:0006813 potassium ion transport
BP IDA GO:0006970 response to osmotic stress
BP IDA GO:0030007 cellular potassium ion homeostasis
BP IDA GO:0034465 response to carbon monoxide
BP IMP GO:0034465 response to carbon monoxide
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Gene expression in normal tissue: KCNMA1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

RTK signaling1

Pathways in KCNMA1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-112316 Neuronal System
reactome R-HSA-1296052 Ca2+ activated K+ channels
reactome R-HSA-1296071 Potassium Channels
reactome R-HSA-392154 Nitric oxide stimulates guanylate cyclase
reactome R-HSA-418346 Platelet homeostasis
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD491 TAE-684 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNMA1

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Cancer
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No matching records found

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