KCNN2


Summary: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
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GO terms in KCNN2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IBA GO:0005516 calmodulin binding
MF IDA GO:0015269 calcium-activated potassium channel activity
MF IBA GO:0016286 small conductance calcium-activated potassium channel activity
MF IDA GO:0016286 small conductance calcium-activated potassium channel activity
MF IMP GO:0016286 small conductance calcium-activated potassium channel activity
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Gene expression in normal tissue: KCNN2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in KCNN2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-112316 Neuronal System
reactome R-HSA-1296052 Ca2+ activated K+ channels
reactome R-HSA-1296071 Potassium Channels
wikipathways WP2380 Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
kegg hsa04726 Serotonergic synapse - Homo sapiens (human)
kegg hsa04911 Insulin secretion - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD536 PLX-4720 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNN2

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Model
Level
Reference ID
Tissue
Cancer
Drug
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Source
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