Summary: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013].

potassium calcium-activated channel subfamily N member 2MIM:605879Ensembl:ENSG00000080709HGNC:HGNC:6291PA300715q22.3

GO terms in KCNN2

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIBAGO:0005516calmodulin binding
MFIDAGO:0015269calcium-activated potassium channel activity
MFIBAGO:0016286small conductance calcium-activated potassium channel activity
MFIDAGO:0016286small conductance calcium-activated potassium channel activity
MFIMPGO:0016286small conductance calcium-activated potassium channel activity
MFISSGO:0016286small conductance calcium-activated potassium channel activity
MFTASGO:0016286small conductance calcium-activated potassium channel activity
MFIPIGO:0019904protein domain specific binding
MFIPIGO:0042803protein homodimerization activity
MFIPIGO:0051393alpha-actinin binding
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0009986cell surface
CCNASGO:0016021integral component of membrane
CCISSGO:0030018Z disc
CCIBAGO:0043005neuron projection
CCIBAGO:0043025neuronal cell body
CCIBAGO:0043197dendritic spine
BPNASGO:0006813potassium ion transport
BPIBAGO:0071805potassium ion transmembrane transport
BPIDAGO:0071805potassium ion transmembrane transport
BPISSGO:0071805potassium ion transmembrane transport
BPISSGO:0098914membrane repolarization during atrial cardiac muscle cell action potential
BPIDAGO:1901379regulation of potassium ion transmembrane transport

Gene expression in normal tissue: KCNN2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNN2

DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296052Ca2+ activated K+ channels
reactomeR-HSA-1296071Potassium Channels
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04976Bile secretion - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNN2