KCNN2
Summary: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium calcium-activated channel subfamily N member 2 | MIM:605879 | Ensembl:ENSG00000080709 | HGNC:HGNC:6291 | PA30071 | 5q22.3 |
GO terms in KCNN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IDA | GO:0015269 | calcium-activated potassium channel activity |
| MF | IBA | GO:0016286 | small conductance calcium-activated potassium channel activity |
| MF | IDA | GO:0016286 | small conductance calcium-activated potassium channel activity |
| MF | IMP | GO:0016286 | small conductance calcium-activated potassium channel activity |
| MF | ISS | GO:0016286 | small conductance calcium-activated potassium channel activity |
| MF | TAS | GO:0016286 | small conductance calcium-activated potassium channel activity |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0051393 | alpha-actinin binding |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | ISS | GO:0030018 | Z disc |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043025 | neuronal cell body |
| CC | IBA | GO:0043197 | dendritic spine |
| BP | NAS | GO:0006813 | potassium ion transport |
| BP | IBA | GO:0071805 | potassium ion transmembrane transport |
| BP | IDA | GO:0071805 | potassium ion transmembrane transport |
| BP | ISS | GO:0071805 | potassium ion transmembrane transport |
| BP | ISS | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential |
| BP | IDA | GO:1901379 | regulation of potassium ion transmembrane transport |
Gene expression in normal tissue: KCNN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNN2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296052 | Ca2+ activated K+ channels |
| reactome | R-HSA-1296071 | Potassium Channels |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| kegg | hsa04976 | Bile secretion - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNN2
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