KCNN4
Summary: The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:602754 Ensembl IDEnsembl:ENSG00000104783 HGNC IDHGNC:HGNC:6293 PHARMGKB IDPA222 Map Location19q13.31 |
GO terms in KCNN4
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEA | GO:0002376 | immune system process |
BP | TAS | GO:0006813 | potassium ion transport |
BP | IDA | GO:0006816 | calcium ion transport |
BP | IEA | GO:0006884 | cell volume homeostasis |
BP | TAS | GO:0006952 | defense response |
BP | IDA | GO:0030322 | stabilization of membrane potential |
Gene expression in normal tissue: KCNN4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNN4
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-112316 | Neuronal System |
reactome | R-HSA-1296052 | Ca2+ activated K+ channels |
reactome | R-HSA-1296071 | Potassium Channels |
kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
kegg | hsa04974 | Protein digestion and absorption - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in KCNN4
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |