Summary: The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008].

potassium calcium-activated channel subfamily N member 4MIM:602754Ensembl:ENSG00000104783HGNC:HGNC:6293PA22219q13.31

GO terms in KCNN4

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0002376immune system process
BPTASGO:0006813potassium ion transport
BPIDAGO:0006816calcium ion transport
BPIEAGO:0006884cell volume homeostasis
BPTASGO:0006952defense response
BPIDAGO:0030322stabilization of membrane potential
BPIEAGO:0045332phospholipid translocation
BPIEAGO:0046541saliva secretion
BPIEAGO:0050714positive regulation of protein secretion
BPIDAGO:0050862positive regulation of T cell receptor signaling pathway
BPIBAGO:0071805potassium ion transmembrane transport
BPIEAGO:0071805potassium ion transmembrane transport
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCICGO:0008076voltage-gated potassium channel complex
CCIBAGO:0043005neuron projection
CCIBAGO:0043025neuronal cell body
MFTASGO:0005267potassium channel activity
MFIPIGO:0005515protein binding
MFIBAGO:0005516calmodulin binding
MFIDAGO:0015269calcium-activated potassium channel activity
MFIBAGO:0016286small conductance calcium-activated potassium channel activity
MFIPIGO:0019903protein phosphatase binding
MFIBAGO:0022894Intermediate conductance calcium-activated potassium channel activity

Gene expression in normal tissue: KCNN4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNN4

DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296052Ca2+ activated K+ channels
reactomeR-HSA-1296071Potassium Channels
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04970Salivary secretion - Homo sapiens (human)
kegghsa04974Protein digestion and absorption - Homo sapiens (human)
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2571Polycystic Kidney Disease Pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNN4