KCNN4


Summary: The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in KCNN4


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0002376 immune system process
BP TAS GO:0006813 potassium ion transport
BP IDA GO:0006816 calcium ion transport
BP IEA GO:0006884 cell volume homeostasis
BP TAS GO:0006952 defense response
BP IDA GO:0030322 stabilization of membrane potential
Showing 1 to 6 of 26 rows rows per page

Gene expression in normal tissue: KCNN4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNN4


Loading, please wait...
Database
Pathway ID
Pathway Des.
reactome R-HSA-112316 Neuronal System
reactome R-HSA-1296052 Ca2+ activated K+ channels
reactome R-HSA-1296071 Potassium Channels
kegg hsa04911 Insulin secretion - Homo sapiens (human)
kegg hsa04970 Salivary secretion - Homo sapiens (human)
kegg hsa04974 Protein digestion and absorption - Homo sapiens (human)
Showing 1 to 6 of 9 rows

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
iGMDRD409 Saracatinib 2
Showing 1 to 2 of 2 rows

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNN4

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​