KCNN4
Summary: The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium calcium-activated channel subfamily N member 4 | MIM:602754 | Ensembl:ENSG00000104783 | HGNC:HGNC:6293 | PA222 | 19q13.31 |
GO terms in KCNN4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002376 | immune system process |
| BP | TAS | GO:0006813 | potassium ion transport |
| BP | IDA | GO:0006816 | calcium ion transport |
| BP | IEA | GO:0006884 | cell volume homeostasis |
| BP | TAS | GO:0006952 | defense response |
| BP | IDA | GO:0030322 | stabilization of membrane potential |
| BP | IEA | GO:0045332 | phospholipid translocation |
| BP | IEA | GO:0046541 | saliva secretion |
| BP | IEA | GO:0050714 | positive regulation of protein secretion |
| BP | IDA | GO:0050862 | positive regulation of T cell receptor signaling pathway |
| BP | IBA | GO:0071805 | potassium ion transmembrane transport |
| BP | IEA | GO:0071805 | potassium ion transmembrane transport |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IC | GO:0008076 | voltage-gated potassium channel complex |
| CC | IDA | GO:0031982 | vesicle |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043025 | neuronal cell body |
| MF | TAS | GO:0005267 | potassium channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IDA | GO:0015269 | calcium-activated potassium channel activity |
| MF | IBA | GO:0016286 | small conductance calcium-activated potassium channel activity |
| MF | IPI | GO:0019903 | protein phosphatase binding |
| MF | IBA | GO:0022894 | Intermediate conductance calcium-activated potassium channel activity |
Gene expression in normal tissue: KCNN4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNN4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296052 | Ca2+ activated K+ channels |
| reactome | R-HSA-1296071 | Potassium Channels |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| kegg | hsa04974 | Protein digestion and absorption - Homo sapiens (human) |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2571 | Polycystic Kidney Disease Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNN4
CLASSFICATION
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