MYO18A
Summary: The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| myosin XVIIIA | MIM:610067 | Ensembl:ENSG00000196535 | HGNC:HGNC:31104 | PA134978348 | 17q11.2 |
Gene Categories:
CELL SURFACEGO terms in MYO18A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| CC | IDA | GO:0005802 | trans-Golgi network |
| CC | IEA | GO:0009986 | cell surface |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0016459 | myosin complex |
| CC | IDA | GO:0042641 | actomyosin |
| BP | IEA | GO:0006259 | DNA metabolic process |
| BP | IEA | GO:0007018 | microtubule-based movement |
| BP | IMP | GO:0007030 | Golgi organization |
| BP | IMP | GO:0016477 | cell migration |
| BP | IMP | GO:0031032 | actomyosin structure organization |
| BP | IMP | GO:0043030 | regulation of macrophage activation |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0048194 | Golgi vesicle budding |
| BP | IMP | GO:0050714 | positive regulation of protein secretion |
| BP | IMP | GO:0090161 | Golgi ribbon formation |
| BP | IMP | GO:0090164 | asymmetric Golgi ribbon formation |
| BP | IMP | GO:1903028 | positive regulation of opsonization |
| MF | IEA | GO:0003677 | DNA binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008017 | microtubule binding |
| MF | IDA | GO:0016887 | ATPase activity |
| MF | IDA | GO:0043531 | ADP binding |
| MF | IDA | GO:0051015 | actin filament binding |
Gene expression in normal tissue: MYO18A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYO18A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYO18A
CLASSFICATION
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