MYO18A
Summary: The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namemyosin XVIIIA OMIM IDMIM:610067 Ensembl IDEnsembl:ENSG00000196535 HGNC IDHGNC:HGNC:31104 PHARMGKB IDPA134978348 Map Location17q11.2 | |||||
Gene Categories:
CELL SURFACEGO terms in MYO18A
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| CC | IDA | GO:0005802 | trans-Golgi network |
| CC | IEA | GO:0009986 | cell surface |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0016459 | myosin complex |
Gene expression in normal tissue: MYO18A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYO18A
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD409 | Saracatinib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYO18A
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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