Summary: The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].

SMAD family member 5MIM:603110Ensembl:ENSG00000113658HGNC:HGNC:6771PA305285q31.1

GO terms in SMAD5

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001657ureteric bud development
BPIEAGO:0001880Mullerian duct regression
BPIEAGO:0002051osteoblast fate commitment
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006468protein phosphorylation
BPNASGO:0007165signal transduction
BPNASGO:0007179transforming growth factor beta receptor signaling pathway
BPIEAGO:0007281germ cell development
BPISSGO:0009880embryonic pattern specification
BPIEAGO:0030218erythrocyte differentiation
BPISSGO:0030509BMP signaling pathway
BPTASGO:0030509BMP signaling pathway
BPIEAGO:0045669positive regulation of osteoblast differentiation
BPNASGO:0045893positive regulation of transcription, DNA-templated
BPIEAGO:0051216cartilage development
BPIEAGO:0060048cardiac muscle contraction
BPIEAGO:0060348bone development
BPISSGO:0060395SMAD protein signal transduction
BPNASGO:0060395SMAD protein signal transduction
BPIEAGO:0071407cellular response to organic cyclic compound
BPISSGO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
BPTASGO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
CCIEAGO:0005667transcription factor complex
CCIDAGO:0032991protein-containing complex
CCNASGO:0071141SMAD protein complex
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIPIGO:0005515protein binding
MFIPIGO:0017151DEAD/H-box RNA helicase binding
MFTASGO:0030618transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
MFIPIGO:0031625ubiquitin protein ligase binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: SMAD5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SMAD5

DatabasePathway IDPathway Des.
pidalk1pathwayALK1 signaling events
pidalk2pathwayALK2 signaling events
pidbmppathwayBMP receptor signaling
humancycPWY66-11BMP Signalling Pathway
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
wikipathwaysWP2895Differentiation of white and brown adipocyte
wikipathwaysWP3876BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation
wikipathwaysWP3927BMP Signaling Pathway in Eyelid Development
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP560TGF-beta Receptor Signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-201451Signaling by BMP
reactomeR-HSA-9006936Signaling by TGF-beta family members
biocartaalkpathwayalk in cardiac myocytes
biocartactcfpathwayctcf: first multivalent nuclear factor

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SMAD5