SMAD5

Summary: The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameSMAD family member 5
OMIM IDMIM:603110
Ensembl IDEnsembl:ENSG00000113658
HGNC IDHGNC:HGNC:6771
PHARMGKB IDPA30528
Map Location5q31.1

GO terms in SMAD5


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0000122 negative regulation of transcription by RNA polymerase II
BP IEA GO:0001657 ureteric bud development
BP IEA GO:0001880 Mullerian duct regression
BP IEA GO:0002051 osteoblast fate commitment
BP IEA GO:0006351 transcription, DNA-templated
BP IEA GO:0006468 protein phosphorylation
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Gene expression in normal tissue: SMAD5

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in SMAD5


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Database
Pathway ID
Pathway Des.
pid alk1pathway ALK1 signaling events
pid alk2pathway ALK2 signaling events
pid bmppathway BMP receptor signaling
humancyc PWY66-11 BMP Signalling Pathway
kegg hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
kegg hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD536 PLX-4720 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SMAD5

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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