NIT1
Summary: This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namenitrilase 1 OMIM IDMIM:604618 Ensembl IDEnsembl:ENSG00000158793 HGNC IDHGNC:HGNC:7828 PHARMGKB IDPA31636 Map Location1q23.3 | |||||
GO terms in NIT1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | HDA | GO:0005634 | nucleus |
| CC | IEA | GO:0005739 | mitochondrion |
| BP | IEA | GO:0006807 | nitrogen compound metabolic process |
| BP | ND | GO:0008150 | biological_process |
| MF | TAS | GO:0000257 | nitrilase activity |
| MF | IBA | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
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Gene expression in normal tissue: NIT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NIT1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD409 | Saracatinib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NIT1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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