P2RY2
Summary: The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600041 Ensembl IDEnsembl:ENSG00000175591 HGNC IDHGNC:HGNC:8541 PHARMGKB IDPA32870 Map Location11q13.4 | |||||
GO terms in P2RY2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0038023 | signaling receptor activity |
| MF | IEA | GO:0045028 | G-protein coupled purinergic nucleotide receptor activity |
| BP | TAS | GO:0006873 | cellular ion homeostasis |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway |
Gene expression in normal tissue: P2RY2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in P2RY2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in P2RY2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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