P2RY2
Summary: The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| purinergic receptor P2Y2 | MIM:600041 | Ensembl:ENSG00000175591 | HGNC:HGNC:8541 | PA32870 | 11q13.4 |
GO terms in P2RY2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0038023 | signaling receptor activity |
| MF | IEA | GO:0045028 | G-protein coupled purinergic nucleotide receptor activity |
| BP | TAS | GO:0006873 | cellular ion homeostasis |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway |
| BP | IEA | GO:0070257 | positive regulation of mucus secretion |
| BP | IEA | GO:0097746 | regulation of blood vessel diameter |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
Gene expression in normal tissue: P2RY2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in P2RY2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-417957 | P2Y receptors |
| reactome | R-HSA-418038 | Nucleotide-like (purinergic) receptors |
| reactome | R-HSA-500792 | GPCR ligand binding |
| reactome | R-HSA-5683826 | Surfactant metabolism |
| biocarta | barrestinpathway | -arrestins in gpcr desensitization |
| biocarta | barrestinsrcpathway | roles of arrestin dependent recruitment of src kinases in gpcr signaling |
| biocarta | barrmapkpathway | role of -arrestins in the activation and targeting of map kinases |
| biocarta | chrebppathway | chrebp regulation by carbohydrates and camp |
| biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| biocarta | gspathway | activation of camp-dependent protein kinase pka |
| biocarta | ionpathway | ionomycin and phorbal ester signaling pathway |
| biocarta | raccpathway | ion channels and their functional role in vascular endothelium |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
| wikipathways | WP80 | Nucleotide GPCRs |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in P2RY2
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