STMN3
Summary: This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| stathmin 3 | MIM:608362 | Ensembl:ENSG00000197457 | HGNC:HGNC:15926 | PA38049 | 20q13.33 |
GO terms in STMN3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0007019 | microtubule depolymerization |
| BP | TAS | GO:0007399 | nervous system development |
| BP | IEA | GO:0031110 | regulation of microtubule polymerization or depolymerization |
| BP | ISS | GO:0031122 | cytoplasmic microtubule organization |
| BP | IBA | GO:0031175 | neuron projection development |
| BP | ISS | GO:0031175 | neuron projection development |
| BP | ISS | GO:0035021 | negative regulation of Rac protein signal transduction |
| BP | ISS | GO:0043087 | regulation of GTPase activity |
| BP | IBA | GO:0051493 | regulation of cytoskeleton organization |
| BP | ISS | GO:0051493 | regulation of cytoskeleton organization |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0030426 | growth cone |
| CC | IBA | GO:0043005 | neuron projection |
| MF | IBA | GO:0015631 | tubulin binding |
| MF | ISS | GO:0019904 | protein domain specific binding |
Gene expression in normal tissue: STMN3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STMN3
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STMN3
CLASSFICATION
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