MED15
Summary: The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607372 Ensembl IDEnsembl:ENSG00000099917 HGNC IDHGNC:HGNC:14248 PHARMGKB IDPA33088 Map Location22q11.21 | |||||
GO terms in MED15
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | HDA | GO:0016020 | membrane |
Gene expression in normal tissue: MED15
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MED15
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1982 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| wikipathways | WP2011 | SREBF and miR33 in cholesterol and lipid homeostasis |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD409 | Saracatinib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MED15
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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