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ASB1

Summary: The protein encoded by this gene contains an ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, targeting them for ubiquitination and degradation. [provided by RefSeq, Aug 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
ankyrin repeat and SOCS box containing 1	MIM:605758	Ensembl:ENSG00000065802	HGNC:HGNC:16011	PA25027	2q37.3

GO terms in ASB1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0061630	ubiquitin protein ligase activity
CC	IDA	GO:0000151	ubiquitin ligase complex
CC	TAS	GO:0005829	cytosol
BP	IDA	GO:0016567	protein ubiquitination
BP	IEA	GO:0016567	protein ubiquitination
BP	IEA	GO:0030539	male genitalia development
BP	IEA	GO:0035556	intracellular signal transduction
BP	NAS	GO:0042036	negative regulation of cytokine biosynthetic process
BP	TAS	GO:0043687	post-translational protein modification

Gene expression in normal tissue: ASB1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ASB1

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-597592	Post-translational protein modification
reactome	R-HSA-8951664	Neddylation
reactome	R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation
reactome	R-HSA-983169	Class I MHC mediated antigen processing & presentation

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD409	Saracatinib	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ASB1

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DATATYPES

CLASSFICATION

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