ASB1

Summary: The protein encoded by this gene contains an ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, targeting them for ubiquitination and degradation. [provided by RefSeq, Aug 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameankyrin repeat and SOCS box containing 1
OMIM IDMIM:605758
Ensembl IDEnsembl:ENSG00000065802
HGNC IDHGNC:HGNC:16011
PHARMGKB IDPA25027
Map Location2q37.3

GO terms in ASB1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IDA GO:0061630 ubiquitin protein ligase activity
CC IDA GO:0000151 ubiquitin ligase complex
CC TAS GO:0005829 cytosol
BP IDA GO:0016567 protein ubiquitination
BP IEA GO:0016567 protein ubiquitination
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Gene expression in normal tissue: ASB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ASB1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-597592 Post-translational protein modification
reactome R-HSA-8951664 Neddylation
reactome R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD409 Saracatinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ASB1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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