ENPP3
Summary: The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602182 Ensembl IDEnsembl:ENSG00000154269 HGNC IDHGNC:HGNC:3358 PHARMGKB IDPA27793 Map Location6q23.2 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in ENPP3
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | IMP | GO:0004528 | phosphodiesterase I activity |
| MF | IEA | GO:0005044 | scavenger receptor activity |
| MF | IDA | GO:0005509 | calcium ion binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0030247 | polysaccharide binding |
Gene expression in normal tissue: ENPP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ENPP3
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP4022 | Pyrimidine metabolism |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| kegg | hsa00500 | Starch and sucrose metabolism - Homo sapiens (human) |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD409 | Saracatinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ENPP3
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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