ENPP3
Summary: The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ectonucleotide pyrophosphatase/phosphodiesterase 3 | MIM:602182 | Ensembl:ENSG00000154269 | HGNC:HGNC:3358 | PA27793 | 6q23.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in ENPP3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | IMP | GO:0004528 | phosphodiesterase I activity |
| MF | IEA | GO:0005044 | scavenger receptor activity |
| MF | IDA | GO:0005509 | calcium ion binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0030247 | polysaccharide binding |
| MF | IEA | GO:0035529 | NADH pyrophosphatase activity |
| MF | IDA | GO:0047429 | nucleoside-triphosphate diphosphatase activity |
| CC | IDA | GO:0009897 | external side of plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | ISS | GO:0002276 | basophil activation involved in immune response |
| BP | IMP | GO:0006220 | pyrimidine nucleotide metabolic process |
| BP | IDA | GO:0006796 | phosphate-containing compound metabolic process |
| BP | IEA | GO:0006898 | receptor-mediated endocytosis |
| BP | IDA | GO:0009143 | nucleoside triphosphate catabolic process |
| BP | IDA | GO:0030505 | inorganic diphosphate transport |
| BP | ISS | GO:0033007 | negative regulation of mast cell activation involved in immune response |
| BP | IDA | GO:0046034 | ATP metabolic process |
| BP | ISS | GO:0050728 | negative regulation of inflammatory response |
| BP | ISS | GO:0070667 | negative regulation of mast cell proliferation |
| BP | IEA | GO:0090305 | nucleic acid phosphodiester bond hydrolysis |
Gene expression in normal tissue: ENPP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ENPP3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP4022 | Pyrimidine metabolism |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| kegg | hsa00500 | Starch and sucrose metabolism - Homo sapiens (human) |
| kegg | hsa00740 | Riboflavin metabolism - Homo sapiens (human) |
| kegg | hsa00760 | Nicotinate and nicotinamide metabolism - Homo sapiens (human) |
| kegg | hsa00770 | Pantothenate and CoA biosynthesis - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-199220 | Vitamin B5 (pantothenate) metabolism |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ENPP3
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.