ENPP3


Summary: The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ectonucleotide pyrophosphatase/phosphodiesterase 3MIM:602182Ensembl:ENSG00000154269HGNC:HGNC:3358PA277936q23.2

Gene Categories:

DRUGGABLE GENOME

GO terms in ENPP3


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003676nucleic acid binding
MFIMPGO:0004528phosphodiesterase I activity
MFIEAGO:0005044scavenger receptor activity
MFIDAGO:0005509calcium ion binding
MFIDAGO:0008270zinc ion binding
MFIEAGO:0030247polysaccharide binding
MFIEAGO:0035529NADH pyrophosphatase activity
MFIDAGO:0047429nucleoside-triphosphate diphosphatase activity
CCIDAGO:0009897external side of plasma membrane
CCIEAGO:0016021integral component of membrane
CCIDAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
BPISSGO:0002276basophil activation involved in immune response
BPIMPGO:0006220pyrimidine nucleotide metabolic process
BPIDAGO:0006796phosphate-containing compound metabolic process
BPIEAGO:0006898receptor-mediated endocytosis
BPIDAGO:0009143nucleoside triphosphate catabolic process
BPIDAGO:0030505inorganic diphosphate transport
BPISSGO:0033007negative regulation of mast cell activation involved in immune response
BPIDAGO:0046034ATP metabolic process
BPISSGO:0050728negative regulation of inflammatory response
BPISSGO:0070667negative regulation of mast cell proliferation
BPIEAGO:0090305nucleic acid phosphodiester bond hydrolysis

Gene expression in normal tissue: ENPP3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ENPP3


DatabasePathway IDPathway Des.
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP4022Pyrimidine metabolism
kegghsa00230Purine metabolism - Homo sapiens (human)
kegghsa00240Pyrimidine metabolism - Homo sapiens (human)
kegghsa00500Starch and sucrose metabolism - Homo sapiens (human)
kegghsa00740Riboflavin metabolism - Homo sapiens (human)
kegghsa00760Nicotinate and nicotinamide metabolism - Homo sapiens (human)
kegghsa00770Pantothenate and CoA biosynthesis - Homo sapiens (human)
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-196849Metabolism of water-soluble vitamins and cofactors
reactomeR-HSA-196854Metabolism of vitamins and cofactors
reactomeR-HSA-199220Vitamin B5 (pantothenate) metabolism

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD409Saracatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ENPP3

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