TRAPPC2L
Summary: This gene encodes a protein that interacts with the tethering factor trafficking protein particle (TRAPP complex). TRAPP complexes mediate the contact between vescicles and target membranes, and thus, are involved in vescicle-mediated transport of proteins and lipids. The encoded protein is related to the X-linked trafficking protein particle complex 2. A related pseudogene is located on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| trafficking protein particle complex 2 like | MIM:610970 | Ensembl:ENSG00000167515 | HGNC:HGNC:30887 | PA145147879 | 16q24.3 |
GO terms in TRAPPC2L
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0048208 | COPII vesicle coating |
| BP | IDA | GO:0051259 | protein complex oligomerization |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0030008 | TRAPP complex |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0017112 | Rab guanyl-nucleotide exchange factor activity |
Gene expression in normal tissue: TRAPPC2L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRAPPC2L
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-204005 | COPII-mediated vesicle transport |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs |
| reactome | R-HSA-9007101 | Rab regulation of trafficking |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRAPPC2L
CLASSFICATION
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