KRT20


Summary: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
keratin 20MIM:608218Ensembl:ENSG00000171431HGNC:HGNC:20412PA13493890717q21.2

GO terms in KRT20


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0005200structural constituent of cytoskeleton
MFIPIGO:0005515protein binding
BPIEAGO:0006915apoptotic process
BPIEAGO:0009267cellular response to starvation
BPTASGO:0031424keratinization
BPIMPGO:0045109intermediate filament organization
BPIEAGO:0050708regulation of protein secretion
BPTASGO:0070268cornification
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCNASGO:0005882intermediate filament

Gene expression in normal tissue: KRT20

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KRT20


DatabasePathway IDPathway Des.
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-6805567Keratinization
reactomeR-HSA-6809371Formation of the cornified envelope

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD450JNJ-268541651

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KRT20

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