BCOR
Summary: The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
NameBCL6 corepressor OMIM IDMIM:300485 Ensembl IDEnsembl:ENSG00000183337 HGNC IDHGNC:HGNC:20893 PHARMGKB IDPA134921737 Map LocationXp11.4 | |||||
GO terms in BCOR
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0000415 | negative regulation of histone H3-K36 methylation |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IMP | GO:0007507 | heart development |
| BP | IMP | GO:0030502 | negative regulation of bone mineralization |
| BP | IDA | GO:0035518 | histone H2A monoubiquitination |
Gene expression in normal tissue: BCOR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCOR
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | hdac_classii_pathway | Signaling events mediated by HDAC Class II |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCOR
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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