iGMDRD669

Canonical SMILES: C1=CC=C(C=C1)C(COC2=CC3=C(C=C2)NC(=O)N3)NC(=O)C4=CC=CN(C4=O)CC5=CC(=C(C=C5)F)F

InChI: InChI=1S/C28H22F2N4O4/c29-21-10-8-17(13-22(21)30)15-34-12-4-7-20(27(34)36)26(35)31-25(18-5-2-1-3-6-18)16-38-19-9-11-23-24(14-19)33-28(37)32-23/h1-14,25H,15-16H2,(H,31,35)(H2,32,33,37)/t25-/m0/s1

InChI Key: GCWCGSPBENFEPE-VWLOTQADSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NamePDK1 inhibitor
CHEMBLCHEMBL1234429
Pubchem CID49766500
Drug StatusAlone
Drug TypeSmall Molecule


Drug Targets:

PDPK1 (PDK1)

Drug Pathways:

Other, kinases

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 4LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Diffuse Large B-Cell Lymphoma (DLBCL) model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1PNtissue: PN cancer: PNS model num: 0PNStissue: PNS cancer: Schwannoma (SCHW) model num: 2

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
4771 NF2 2
9757 KMT2B 2
8452 CUL3 1
1029 CDKN2A 1
Showing 1 to 4 of 8 rows

Gene in drug-gene network: Network Plot

Models in PDK1 inhibitor

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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