SMPD3

Summary:

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namesphingomyelin phosphodiesterase 3
OMIM IDMIM:605777
Ensembl IDEnsembl:ENSG00000103056
HGNC IDHGNC:HGNC:14240
PHARMGKB IDPA37862
Map Location16q22.1

GO terms in SMPD3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0004767 sphingomyelin phosphodiesterase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0046872 metal ion binding
BP IEA GO:0002244 hematopoietic progenitor cell differentiation
BP TAS GO:0006685 sphingomyelin catabolic process
BP IEA GO:0007049 cell cycle
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Gene expression in normal tissue: SMPD3

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 3

Gene-drug pathway distribution

Protein stability and degradation1ERK MAPK signaling1RTK signaling1

Pathways in SMPD3


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Database
Pathway ID
Pathway Des.
pid ceramide_pathway Ceramide signaling pathway
humancyc PWY3DJ-11281 sphingomyelin metabolism/ceramide salvage
netpath Pathway_TNFalpha TNFalpha
kegg hsa00600 Sphingolipid metabolism - Homo sapiens (human)
reactome R-HSA-1430728 Metabolism
reactome R-HSA-162582 Signal Transduction
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD491 TAE-684 1
iGMDRD353 PD0325901 1
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SMPD3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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