SMPD3
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sphingomyelin phosphodiesterase 3 | MIM:605777 | Ensembl:ENSG00000103056 | HGNC:HGNC:14240 | PA37862 | 16q22.1 |
GO terms in SMPD3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004767 | sphingomyelin phosphodiesterase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0002244 | hematopoietic progenitor cell differentiation |
| BP | TAS | GO:0006685 | sphingomyelin catabolic process |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IEA | GO:0030072 | peptide hormone secretion |
| BP | ISS | GO:1903543 | positive regulation of exosomal secretion |
| BP | TAS | GO:2000304 | positive regulation of ceramide biosynthetic process |
| CC | IEA | GO:0000137 | Golgi cis cisterna |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0005886 | plasma membrane |
Gene expression in normal tissue: SMPD3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SMPD3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ceramide_pathway | Ceramide signaling pathway |
| humancyc | PWY3DJ-11281 | sphingomyelin metabolism/ceramide salvage |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa00600 | Sphingolipid metabolism - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1660662 | Glycosphingolipid metabolism |
| reactome | R-HSA-428157 | Sphingolipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5626978 | TNFR1-mediated ceramide production |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75893 | TNF signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SMPD3
CLASSFICATION
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